BACKGROUND The recent emergence of autologous blood concentrates, such as platelet-rich plasma, as a treatment option for patients with orthopaedic injuries has led to an extensive debate about their clinical benefit. We conducted a systematic review and meta-analysis to determine the efficacy of autologous blood concentrates in decreasing pain and improving healing and function in patients wit...

Background: Alopecia areata (AA) is a non-scarring, autoimmune, inflammatory condition that causes well-defined areas of hair loss on the scalp and/or body. A new biotechnology called platelet-rich plasma (PRP) was developed as result increased interest in tissue engineering and cell-based therapies. This therapy defined an autologous, non-allergic preparation platelets concentrated plasma. Stu...

One explanation for why downstream gonadotropin protocol changes during IVF commonly arrive too late to have significant effects is that embryo development actually begins during oogenesis. Thus, efforts to modify the chromosomal status of blastocysts must address the ovarian milieu well in advance of follicular recruitment. A 42 years old woman with primary infertility of 3 years duration atte...

OBJECTIVES To report outcomes after sclerosing, platelet-rich plasma (PRP) and autologous blood injection therapies as a treatment for tendinopathy. METHODS We searched Pubmed for clinical trials on sclerosing, PRP and autologous blood injections for tendinopathy. We scored the quality of the studies using a modified Coleman Methodological Score (CMS) with 9 criteria, which results in a final...

Knee osteoarthritis (OA) is a usual problem in the elderly population, which treated with lifestyle modifications, non-steroidal anti-inflammatory drugs, physiotherapy, and intraarticular injections of corticosteroids/hyaluronic acid/autologous platelet-rich plasma (PRP) early stages, late surgical procedures, such as arthroscopic debridement, unicompartmental arthroplasty, patellofemoral total...

Introduction: Autologous platelet-rich plasma (PRP) has been a growing trend in the field of medicine due to its broad range application and is considered safe from bloodborne diseases. Furthermore, various studies have tried optimize use autologous PRP through preparation protocols, including activation. However, most available not evaluated safety for intravenous delivery PRP, especially acti...

BACKGROUND Beside autoimmunity, coagulation pathway is also involved in the pathogenesis of chronic urticaria (CU). Previous studies showed that plasma D-dimer levels paralleled the severity of the disease. To date, there are no data concerning D-dimer level in Thai patients with CU. OBJECTIVE This study aimed to find the relationship between plasma D-dimer levels and the disease severity of ...

Objective(s): Autologous bone transplantation known as the “gold standard” to reconstruction of osseous defects has known disadvantages. This study was designed to explore the effects of hydroxy-apatite/tricalcium-phosphate (HA/TCP) and platelet-rich plasma (PRP) on the osteogenesis ability of human adipose-derived mesenchymal stem cells (hAdMSCs) in vitro and in vivo. Materials and Methods: hA...