We exhibit a triangulated category T having both products and coproducts and a triangulated subcategory S ⊂ T which is both localizing and colocalizing, and for which neither a Bousfield localization nor a colocalization exists. It follows that neither the category S nor its dual satisfy Brown representability. Our example involves an abelian category whose derived category does not have small ...

Given a pseudomonad $mathcal{T} $ on a $2$-category $mathfrak{B} $, if a right biadjoint $mathfrak{A}tomathfrak{B} $ has a lifting to the pseudoalgebras $mathfrak{A}tomathsf{Ps}textrm{-}mathcal{T}textrm{-}mathsf{Alg} $ then this lifting is also right biadjoint provided that $mathfrak{A} $ has codescent objects. In this paper, we give  general results on lifting of biadjoints. As a consequence, ...

BACKGROUND Leukocyte function-associated antigen 1 (LFA-1), consisting of CD11a and CD18 subunits, plays an important role in T-cell activation and leukocyte extravasation. OBJECTIVE To test whether blocking CD11a decreases immunobiologic and clinical activity in psoriatic plaques. DESIGN Open-label, multicenter, dose escalation study. PATIENTS Thirty-nine patients with moderate-to-severe...

Let k be an algebraically closed field and let T be the k-linear algebraic triangulated category generated by a w-spherical object for an integer w. For certain values of w this category is classical. For instance, if w = 0 then it is the compact derived category of the dual numbers over k. As main results of the paper we show that for w ≤ 0, the category T has no non-trivial t-structures, but ...

In this paper, some categorical properties of the category ${bf Cpo}_{{bf Act}text{-}S}$ of all {cpo $S$-acts}, cpo's equipped with actions of a monoid $S$ on them, and strict continuous action-preserving maps between them is considered. In particular, we describe products and coproducts in this category, and consider monomorphisms and epimorphisms. Also, we show that the forgetful functor from...