background: hydrocarbons degradation is principally achieved by microorganisms in natural environments. the extent of hydrocarbons biodegradation is mainly conditioned by environmental factors and its success depends on the optimal condition for the crude oil degrading isolates. objectives: the aims of the current study was to isolate and identify crude oil degrading bacterium from surface sedi...

Chemical process simulations depend on physical properties, which are usually available through property models with parameters estimated from experiments. The required experimental effort can be reduced using the method of Optimal Experimental Design (OED). OED reduces number experiments by minimising expected uncertainty parameters. In chemical engineering, however, main purpose an experiment...

Popular algorithms for optimal design do not account for non-exchangeability of the basic experimental units. This paper introduces an algorithm for searching for D-optimal experimental designs in the presence of certain kinds of non-exchangeability|in particular, when there are xed covariates associated with units and/or when the units have a non-trivial covariance structure; this algorithm ex...