Since its inception as a diagnostic category in 1980, the definitional criteria for generalized anxiety disorder (GAD) have been revised substantially in each edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM). In DSM-III (American Psychiatric Association, 1980), GAD was a residual category (i.e., diagnosis was permitted only if criteria were not met for any other Axis I...

OBJECTIVE While adolescent anxiety disorders represent prevalent, debilitating conditions, few studies have explored their brain physiology. Using event-related functional magnetic resonance imaging (fMRI) and a behavioral measure of attention to angry faces, the authors evaluated differences in response between healthy adolescents and adolescents with generalized anxiety disorder. METHOD In ...

The present investigation examined the interpersonal functioning of undergraduate students who met self-report criteria for generalized anxiety disorder (GAD), both as they perceive it and as perceived by their self-nominated friends. Forty-eight participants who met self-report criteria for GAD endorsed greater global severity of interpersonal problems on the 64-item version of the Inventory o...

Feltner DE, Crockatt JG, Dubovsky SJ, et al. A randomized, double-blind, placebo-controlled, fixeddose, multicenter study of pregabalin in patients with generalized anxiety disorder. J Clin Psychopharmacol 2003;23:240–9. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

Subjects from a family study who had panic disorder and generalized anxiety disorder were compared on the pattern of their symptoms, age and type of onset, personality characteristics, course of illness, and outcome. Subjects with generalized anxiety disorder were shown to have fewer autonomic symptoms and an earlier, more gradual onset. Their illness was also observed to have a more chronic co...

Worry is a common phenomenon in children and adolescents, with some experiencing excessive worries that cause significant distress and interference. The metacognitive model of generalized anxiety disorder (Wells 1995, 2009) was developed to explain cognitive processes associated with pathological worry in adults, particularly the role of positive and negative beliefs about worry. This review ev...