The bacterial iron response regulator (Irr) protein mediates iron-dependent regulation of heme biosynthesis. Pulse-chase and immunoprecipitation experiments showed that Irr degraded in response to 6 microM iron with a half-life of approximately 30 min and that this regulated stability was the principal determinant of control by iron. Irr contains a heme regulatory motif (HRM) near its amino ter...

BACKGROUND Identification of specific mutation targets in cancer may lead to discovery of the genes modulating cancer susceptibility and/or prognosis. The RGSL1, RGS16, and RGS8 genes within the 1q25.3 region belong to the novel family of regulators of G protein signaling (RGS) genes, which increase the GTPase activity of the Gα subunit to attenuate signaling from the G protein-coupled receptor...

Kessing BF, Weijenborg PW, Smout AJ, Hillenius S, Bredenoord AJ. Water-perfused esophageal high-resolution manometry; normal values and validation. Am J Physiol Gastrointest Liver Physiol 306: G491–G495, 2014. First published January 30, 2014; doi:10.1152/ajpgi.00447.2013.—Water-perfused high-resolution manometry (HRM) catheters with 36 unidirectional pressure channels have recently been develo...

The purpose of the present study was to determine whether using hydrogen-rich medium (HRM) to increase hydrogen levels in endothelial cells (ECs) protects ECs from apoptosis induced by advanced glycation end products (AGEs). The thoracic aorta was removed from 2-3-year-old Sprague-Dawley rats, and ECs were isolated and cultured. After culturing ECs in the presence of AGEs and/or with HRM for 24...

More and more HRM systems today are being changed to e-HRM systems in China. This is mainly due to the advent of Internet technology and the emerging concept of business intelligence. This study shows the evolution of information systems and information processing in the HRM domain and provides an implementation case in a large Chinese state-run enterprise. The experiences and lessons learned f...

This paper explores empirically future developments in information and communication technology (ICT) and its implications for human resource management (HRM). The paper applies the Delphi method and draws on a panel of anonymous experts comprising e-HRM academics from Europe and e-HRM practitioners from Finland. Findings indicate that developments in social media are believed to have several m...

To compare the effects of high-load, low-repetition maximum (LRM) and low-load, high-repetition maximum (HRM) resistance training regimens on muscular fitness in untrained adolescents. Forty-five untrained adolescents of both sexes (13.7±0.8 years; 161.3±7.5 cm, 56.8±13.4 kg) were randomly assigned into one of three groups: 1) LRM (n = 17): volunteers performed three sets of 4-6-repetition maxi...

Theory building has lagged on the intermediate linkages responsible for the relationship between HRM and firm performance. We introduce the construct “strength of the HRM system” and describe the metafeatures of an HRM system that result in a strong organizational climate, analogous to Mischel’s “strong situation,” in which individuals share a common interpretation of what behaviors are expecte...