The rodent Pig-a assay is a flow cytometric, phenotype-based method used to measure in vivo somatic cell mutation. An Organization for Economic Co-operation and Development (OECD) test guideline currently being developed support routine use of the regulatory purposes (OECD project number 4.93). This article provides advice on best practices designing conducting studies evaluating substance safe...

Haplorchis  taichui is parasitic heterophyidae(trematoda) which lives in the intestinal mucosa of its main host and producing heterophyidosis,which is a zonootic diseases.subsequent to the authors, provious  studies which were made on parasit,s lift  cycle in nature in Khuzestan province,Iran,this experimental study was performed with the aim of establishing the parasite,s lift cycle in laborat...

There could hardly be two more disparate uses of the word “model” than animal model and nonstandard model of arithmetic. One refers to a biological organism, the other to a mathematical structure. The term animal model is used to describe the employment of an animal bred specifically for laboratory use to study some physiological process, such as the employment of laboratory rats to study the e...

BACKGROUND: In the present study, the submandibularsalivary gland microscopic morphology of the adult Africangiant pouched rat was investigated. This study was carried out toprovide the basic histology of this organ in the giant pouched rat,to accompany the dearth of information of its microscopicarchitecture in the available literature. This becomes of evenhigher importance when considering th...

In this study we examine the size of primary sensory areas in the neocortex and the cellular composition of area 17/V1 in three rodent groups: laboratory nocturnal Norway rats (Long-Evans; Rattus norvegicus), wild-caught nocturnal Norway rats (R. norvegicus), and laboratory diurnal Nile grass rats (Arvicanthis niloticus). Specifically, we used areal measures of myeloarchitecture of the primary ...

The laboratory rat, Rattus norvegicus, was the first mammalian species domesticated for scientific research, which work dating back to before 1850. From this auspicious beginning, the rat has become the most widely studied experimental animal model for biomedical research (Jacob, 1999). Since the development of the first inbred rat strain by King 1909, over 500 inbred rat strains have been deve...

The rat model of Pneumocystis carinii pneumonia is frequently used to study human P. carinii infection, but there are many differences between the rat and human infections. We studied naturally acquired P. carinii in wild rats to examine the relevance of the rat model for human infection. P. carinii DNA was detected in 47 of 51 wild rats and in 10 of 12 nonimmunosuppressed laboratory rats. Evid...

Interest in hydroxy - carboxylic acid 2 (HCA2) receptor has been raised since it is the target of antidyslipidemic drug nicotinic acid. The present study aimed to evaluate the presence of mRNA of this receptor in different organs of laboratory rat. Twenty two different organs of rats including mesenteric fat, epididymis (head, body and tail), testis, ovary, xiphoid process, liver, adrenal gland...