In the United States alone, there were an estimated 76,380 new cases of melanoma and an estimated 6,750 deaths due to melanoma in 2016 (Siegel, Miller, & Jemal, 2016). Early screening can increase life expectancy (Freedberg et al., 1999), but melanoma left undiagnosed can be fatal. Dermatologists use many heuristic classification methods to diagnose melanoma (Argenziano et al., 1998; Nachbar et...

Topiramate (TPM) is an antiepileptic drug also used in migraine prophylaxis (Silberstein et al. 2007). Neuropsychiatric symptoms may emerge during the use of TPM (Fröscher et al. 2005). There are few reports showing a link between psychotic adverse events and use of TPM (Khan et al. 1999). Only one patient with schizoaffective disorder has been reported in the litera ture, who complained of dos...

As soon as researchers uncovered microorganisms’ abilities to communicate, efforts began to control the conversation. Among other cellular functions, quorum-sensing is implicated in biofilm formation, a problematic phenomena in a variety of settings such as persistence of infections (Costerton et al., 1999; Rutherford and Bassler, 2012) and biofouling of waterand wastewatertreatment membranes (...

1. introduction current statistical methods may be unable to accurately predict recurrence intervals of rare, large magnitude floods. the usual procedure involves extrapolation from gauged hydrological records documenting 30–40 year records of observed (normally small) floods to the estimation of the quantifies and recurrence intervals of very large, rare floods. this conventional approaches be...

Conjugated linoleic acid (CLA) has recently attracted considerable attention as a health-promoting substance. For example, CLA has been reported to prevent carcinogenesis (Pariza and Hargraves, 1985), atherosclerosis (Nicolosi et al., 1997), and tumorigenesis (Ha et al., 1990; Ip et al., 1991), to improve hyperinsulinemia (Houseknecht et al., 1998), and to modulate immune activity (Cook et al.,...