نتایج جستجو برای: mitochondrial pathway
تعداد نتایج: 433824 فیلتر نتایج به سال:
Mitochondrial DNA mutations and defects in mitochondrial enzymes have been identified in gastric cancers, and they might contribute to cancer progression. In previous studies, mitochondrial dysfunction was induced by oligomycin-enhanced chemoresistance to cisplatin. Herein, we dissected the regulatory mechanism for mitochondrial dysfunction-enhanced cisplatin resistance in human gastric cancer ...
Transmissible gastroenteritis virus (TGEV), a member of the coronaviridae family, could cause fatal diarrhea of piglets and result in numerous economic losses. Previous studies demonstrated that TGEV infection could lead to mitochondrial damage and upregulate miR-4331 level. So miR-4331 may play an important regulatory role in the control of mitochondrial function. To explore the potential role...
Import and assembly of mitochondrial proteins depend on a complex interplay of proteinaceous translocation machineries. The role of lipids in this process has been studied only marginally and so far no direct role for a specific lipid in mitochondrial protein biogenesis has been shown. Here we analyzed a potential role of phosphatidic acid (PA) in biogenesis of mitochondrial proteins in Sacchar...
Carbohydrates, principally glycogen, trehalose, and glucose, are the energy reserves for the flight of flies. Glycogen deposits are found in the soluble cytoplasm of the muscle, and the initial reactions of glycogen, trehalose, or glucose catabolism are localized in the cytoplasm (1). During glycolysis, the first oxidative step occurs at the triose level and reduced coenzyme, reduced diphosphop...
Background: Non-alcoholic fatty liver disease (NAFLD) is an important cause of chronic liver disease worldwide. Mitochondrial dysfunction has been proven to be closely associated with NAFLD. The aim of this study is to investigate the effect of interval exercise and omega-3 on mitochondrial biogenesis in liver tissues of NAFLD rats. Materials and Methods: In this experimental study, 40 male Wis...
Background and purpose: Anti-apoptotic protein Bcl-2 prevents apoptosis through the mitochondrial pathway and high-level expression of Bcl-2 is required for survival of chronic lymphocytic leukemia (CLL). Berberine (BBR) is an alkaloid that induces apoptosis of cancer cells via mitochondrial pathways. The aim of this study was to investigate the effect of Berberine on Bcl-2 gene expression in p...
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