Transcription suppressor Musculin (MSC) is enriched in pro-inflammatory Th17 and IL-22-producing ILC3s. While MSC+/+ mice survived DSS-induced colitis, MSC−/− showed elevated cytokines with severer pathology, reduced body weight, earlier death. Reversal of colitis symptoms by IL-22 antagonism suggests the existence MSC:IL-22 regulatory axis.

Background: Mesenchymal stem cells (MSCs) are considered as effective therapeutic cells in transplantation due to their immunomodulatory activities. However, precise mechanism of MSCs immunomodulatory activity is not completely understood. Objectives: To study the role of Immunoglobulin-like transcripts-3 (ILT3) immunomodulatory receptor in immune tolerance induced by MSCs in skin transpla...

OBJECTIVE To suggest an appropriate denominator for use with the statistic "potential years of life lost", in order to facilitate valid comparisons between health authorities. DESIGN Analysis of OPCS population and mortality data for the period 1987-91. SETTING Data for Wales were analysed to provide comparisons between the nine district health authorities. SUBJECTS There were 46,139 male...

We consider a spectrum of geometric optimization problems motivated by contexts such as satellite communication and astrophysics. In the problem Minimum Scan Cover with Angular Costs , we are given graph G that is embedded in Euclidean space. The edges need to be scanned, i.e., probed from both their vertices. To scan edge, two vertices face each other; changing heading vertex incurs some cost ...

All ribosomal protein (rp) gene promoters from Saccharomyces cerevisiae studied so far contain either (usually two) binding sites for the global gene regulator Rap1p or one binding site for another global factor, Abf1p. Previous analysis of the rpS33 and rpL45 gene promoters suggested that apart from the Abf1 binding site, additional cis-acting elements play a part in transcription activation o...

several practical problems of hypotheses testing can be under a general linear model analysis of variance which would be examined. in analysis of variance, when the response random variable y , has linear relationship with several random variables x, another important model as analysis of covariance can be used. in this paper, assuming that y is fuzzy and using dlr metric, a method for testing ...

Nanovesicles In article 2300315 by Jiacan Su, Meng Li, Jie Gao, and co-workers, GelMA-NVs, defined as gelatin methacryloyl hydrogels loaded with exosome-mimicking mesenchymal stem cell-derived nanovesicles (MSC-NVs), exhibit sustained release of MSC-NVs which could increase chondrocyte human bone marrow MSC differentiation, proliferation, migration induce M2 macrophage polarization.

Objective: We aimed to determine the significance of MSC-derived exosomes (MSC-Exos) in chondrocyte autophagy under normal and inflammatory conditions.