background :    acinetobacter baumannii has become one of the most important causes of nosocomial infections in recent years. the organism seems to be resistant to most classes of antibiotics. carbapenems are considered the most effective drugs for treatment of these infections. however, increasing emergence of carbapenem resistant a. baumannii has become a major healthcare problem.   methods :...

objective: aminoglycosides are highly potent, broad-spectrum antibiotics with many desirable properties for the treatment of life-threatening infections. escherichia coli (e. coli) is the most common cause of urinary tract infection (uti). antibiotic resistance has recently become prevalent. enzymatic inactivation of aminoglycosides by aminoglycoside-modifying enzymes is the main mechanism of r...

conclusions the clinical klebsiella strains isolated from lahore region, pakistan exhibited resistance to most commonly used antibiotics, which can be a serious threat to public health. the study reported some potential actinomycetes strains, which exhibit promising activity against multidrug resistant klebsiella strains. results the isolated klebsiella strains showed resistance against most of...

BACKGROUND Most clinical isolates that exhibit a multi-drug resistant phenotype owe that resistance to over-expressed efflux pumps. Compounds that are efflux pump inhibitors (EPIs) reduce or reverse resistance to antibiotics to which the bacterial strain is initially resistant. We have evaluated non-antibiotics to reduce resistance of commonly encountered bacterial pathogens to antibiotics. M...

Colistin relates to the polymyxin group of antibiotics. This antibiotic is still used to destroy gram-negative bacteria as a last resort. However, resistance to this antibiotic has been reported and is appearing day by day. Not much information is available on the exact mechanisms of resistance to this antibiotic. Also, not enough information about pharmacokinetics and pharmacodynamics is avail...

abstract background: a surgical site infection (ssi) is the most common nosocomial infection after surgery and is the third most common infection in hospitalized patients. the aim of this study was to asses minimum inhibitory concentration (mic) of the causing agents of ssi and antimicrobial susceptibility patterns. methods: this cross-sectional study was done in three referral hospitals in nor...

objective(s): pseudomonas aeruginosa is a nosocomial pathogen resistant to most antimicrobial treatments. furthermore, it persists in adverse environments thereby forming biofilms on various surfaces. researchers have therefore focused on antibiofilm strategies using nanoparticles due to their unique physicochemical properties. superparamagnetic iron oxide nanoparticles (sionps) have recently s...