the culture media optimization is an inevitable part of upstream process development in therapeutic monoclonal antibodies (mabs) production. the quality by design (qbd) approach defines the assured quality of the final product through the development stage. an important step in qbd is determination of the main quality attributes. during the media optimization, some of the main quality attribute...

in this study, modeling and optimization of coagulation and flocculation processes in cod removal of galvanized wastewater treatment plant of mobarakeh steel complex (msc) were studied. experiments of this study were designed using response surface method which is one of the most efficient methods in experimental design. the variables assessed in this study, are four factors including ph, input...

A new scheme to cope with two-stage stochastic optimization problems uses a risk measure as the objective function of the recourse action, where the risk measure is defined as the worst-case expected values over a set of constrained distributions. This paper develops an approach to deal with the case where both the first and second stage objective functions are convex linearquadratic. It is sho...

In this paper, a stochastic two-stage model is offered for optimization of the day-ahead scheduling of the microgrid. System uncertainties including dispatchable distributed generation and energy storage contingencies are considered in the stochastic model. For handling uncertainties, Monte Carlo simulation is employed for generation several scenarios and then a reduction method is used to decr...

This paper considers a three-stage assembly flowshop scheduling problem with sequence-dependent setup < /div> times at the first stage and blocking times between each stage in such a way that the weighted mean completion time and makespan are minimized. Obtaining an optimal solution for this type of complex, large-sized problem in reasonable computational time using traditiona...

In this paper the torsion bar optimization problem of reliability is considered. Since this problem is a difficult optimization problem, an improved intelligent ant colony algorithm is proposed to solve the problem. This algorithm comprises five stages. First stage is the initialization of pheromone and the sensor node configuration. The second stage is to select the next sensor node. The third...

Nowadays, numerous processes of any supply chain are done by suppliers and consequently they cause a massive amount of pollution released to the nature. Hence, greening the suppliers has become a necessity. Although most of green supplier development programs need high investment, formal optimization models that address this issue are very rare. This paper mainly aims to address this prob...

We consider barrier problems associated with two and multistage stochastic convex optimization problems. We show that the barrier recourse functions at any stage form a selfconcordant family with respect to the barrier parameter. We also show that the complexity value of the first stage problem increases additively with the number of stages and scenarios. We use these results to propose a proto...

We present a constraint-and-column generation algorithm to solve two-stage robust optimization problems. Compared with existing Benders style cutting plane methods, it is a general procedure with a unified approach to deal with optimality and feasibility. A computational study on a two-stage robust location-transportation problem shows that it performs an order of magnitude faster. Also, it rev...