The assembly of heteromeric protein complexes is an inherently stochastic process in which multiple genes are expressed separately into proteins, which must then somehow find each other within the cell. Here, we considered one of the ways by which prokaryotic organisms have attempted to maximize the efficiency of protein complex assembly: the organization of subunit-encoding genes into operons....

We consider the stochastic graph model where the location of each vertex is a random point in a given metric space. We study the problems of computing the expected lengths of the minimum spanning tree, the minimum perfect matching and the minimum cycle cover on such a stochastic graph and obtain an FPRAS (Fully Polynomial Randomized Approximation Scheme) for each of these problems. Our result f...

Capacitated location-allocation problem with stochastic demands is originally formulated as expected value model, chance-constrained programming and dependent-chance programming according to different criteria. For solving these stochastic models efficiently, the network simplex algorithm, stochastic simulation and genetic algorithm are integrated to produce a hybrid intelligent algorithm. Fina...

Facility location decisions are a critical element in strategic planning for a wide range of private and public ®rms. The rami®cations of siting facilities are broadly based and long-lasting, impacting numerous operational and logistical decisions. High costs associated with property acquisition and facility construction make facility location or relocation projects long-term investments. To ma...

This study presents a multimodal hub location problem which has the capability to split commodities by limited-capacity hubs and transportation systems, based on the assumption that demands are stochastic for multi-commodity network flows. In the real world cases, demands are random over the planning horizon and those which are partially fulfilled, are lost. Thus, the present study handles dema...

Stochastic performance models have been widely used to analyse the performance and reliability of systems that involve the flow and processing of customers and/or resources with multiple service centres. However, the quality of performance analysis delivered by a model depends critically on the degree to which the model accurately represents the operations of the real system. This paper present...

From the most important issues in the design of large logistics network in times of crisis are providing a timely quick reaction for treating of injured people and the rapid distribution of medicines and medical equipment. In this paper, a multi-objective model is presented that aims to determine the location of transfer points and hospitals to provide timely quick reaction for treating injured...