The hepatic uptake rate for certain albumin-bound drugs and metabolites correlates poorly with their equilibrium unbound concentration in the plasma, suggesting that binding equilibrium may not always exist within the hepatic sinusoids. Currently available models for the uptake process assume binding equilibrium and, thus, cannot be used to investigate this possibility. This report presents a m...

Pulse vaccination is an effective and important strategy for the elimination of infectious diseases. A delayed SEIRS epidemic model with pulse vaccination and varying total population size is proposed in this paper. We point out, if R* < 1, the infectious population disappear so the disease dies out, while if R(*) > 1, the infectious population persist. Our results indicate that a long period o...

The pharmacokinetic parameters of ceftazidime, a third generation cephalosporin, were investigated in six buffalo calves after single intravenous (IV) and intramuscular (IM) administration at a dose rate of 10 mg/kg body weight. Ceftazidime concentrations in plasma and urine were determined by microbiological assay. Ceftazidime disposition was best fitted by a two-compartmental and a one-compar...

this study is concerned with understanding the impact of demographic changes, socioeconomic inequalities, and the availability of health factors on life expectancy (le) in the low and lower middle income countries.the cross-country data were collected from 91 countries from the united nations agencies in 2012. le is the response variable with demographics (total fertility rate, and adolescent f...

Understanding the reaction path and mechanism of chlorinated volatile organic compound (CVOC) destruction is important for designing efficient catalysts, especially application noble metal-based materials. Herein, several typical metals, Ru, Rh, Pt, Pd, Au, Ir, supported on γ-Al2O3 catalysts were synthesized by hydrazine hydrate reduction method 1,2-dichloroethane (1,2-DCE) elimination. Various...

elimination of potyviruses from two commercial iranian garlic populations, hamedan and azar-shahr, through thermotherapy and by meristem tip culture were investigated. the infected bulbs of either one of the populations were initially treated at 30o c for one week and then at 36oc for 5 weeks. the meristems of cloves at two sizes of 0.4-0.6 mm and 0.6-0.8 mm were then cultured on ms medium supp...

Isozyme 3a of rabbit hepatic cytochrome P-450, also termed P-450ALC, was previously isolated and characterized and was shown to be induced 3- to 5-fold by exposure to ethanol. In the present study, antibody against rabbit P-450ALC was used to identify a homologous protein in alcohol dehydrogenase-negative (ADH-) and -positive (ADH+) deermice, Peromyscus maniculatus. The antibody reacts with a s...