Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality in young adults and children, and is a leading public health problem worldwide. In TBI, neurological impairment is caused by immediate brain tissue disruption (primary injury) and post‑injury cellular and molecular events (secondary injury) that exacerbate the primary neurological insult. However, the destructi...

Introduction: This study was designed to investigate the effects of granulocyte colony-stimulating factor (G-CSF) administration in rats for 6 weeks after traumatic brain injury (TBI). Methods: Adult male Wistar rats (n = 30) were injured with controlled cortical impact device and divided into four groups. The treatment groups (n = 10 each) were injected subcutaneously with recombinant human...

conclusions the findings of this study indicated that the economic burden of tbis was high in fatal accidents in fars province so that it was equivalent to 0.00011% of iran’s gross domestic product (gdp) in 2013. therefore, more attention has to be paid to the rules to prevent the fatal accidents. results deaths resulting from tbis due to traffic accidents in shiraz imposed 6.2 billion rials (5...

a motor vehicle seat belt use law for the driver and front-seat passenger was implemented in taiwan on june 1, 2001. the purpose of this study was to determine the effect of motor vehicle seat belt use on the severity of traumatic brain injuries because of motor vehicle accidents.data were collected from 27 major teaching hospitals four years before june 1, 2001 and until may 31, 2013. a total ...

Traumatic brain injury is considered as one of the main causes of morbidity and mortality worldwide. Apart from primary mechanical injury, Secondary injuries due to inflammation and apoptosis result in great neuronal damage. Current treatments are not able to regenerate the damaged part and prevent future sequels. Using human stem cells with self-assembling scaffolds may be promising in treatme...

although the majority of the patients with traumatic brain injury presents with injuries involving the extremities, there was a clear paucity of adequate experimental polytrauma models. to close this gap, we conducted several studies to establish two different polytrauma mice models including both closed and open traumatic brain injury. male c57bl mices with a mean weight of 23g were anesthetiz...

objective: to determine the prediction value of disorder of consciousness scale (docs) for consciousness recovery after traumatic brain injury (tbi) leading to coma. methods: this is a descriptive-cross-sectional study of the correlation between the level of patients’ consciousness in the first and second weeks and the first 2 months after traumatic brain injury, using docs scale. results: the ...