background: immunization against diphtheria, tetanus and pertussis has been applied in iran since 1950. who suggests periodical evaluation of effectiveness of the triple diphtheria-tetanus-whole cell pertussis (dtwp) vaccine, worldwide. objectives: to determine the immunogenicity of locally manufactured dtwp vaccine administered to preschool children in a number of health centers of tehran in 2...

background and aims: influenza vaccination is one of the best way to prevent and control influenza worldwide. it is manufactured by who-licensed companies based on the who expertise committee annually. the aim of this study was partial quality control of the commercial human influenza vaccine 2008-9 and its matching with the circulating strains. materials and methods: the trivalent imported vac...

background: hepatitis b infection is a major public health problem worldwide. dental students who are frequently in contact with body fluids like blood and saliva are still at high risk for hbv exposure. the aim of this study was to evaluate the effectiveness of hbv vaccine and personal factors associated with serologic evidence of the immune response. methods: a descriptive-cross sectional stu...

background: hepatitis c (hcv) is a worldwide problem without an effective vaccine with more than 170 million chronically infected people worldwide. dna vaccines expressing antigenic portions of the virus with adjutants have recently been developed as a novel vaccination technology. objectives: in the present study, a dna vaccine expressing hcv core protein was developed with il12 as a genetic a...

considering the circulation of bordetella pertussis clinical strains among populations with high vaccination coverage, it is necessary to have a proper understanding of this bacterium causing whooping cough. various techniques, which are available for studying b. pertussis, can facilitate a proper comparison between different populations. we genotypically analyzed a collection of two vaccine st...

In this study, the immunogenicity of a rabies vaccine that was used in one of the Isfahan cattle farms is reported. This vaccine was produced by replication of the Pasteur virus (PV) strain on BHK-21 monolayer cell culture. The virus suspension was inactivated by ß-propiolactone treatment and the harvested pool showed sterility and safety. Thus, the obtained vaccine was tested on mice and a sat...

background: cationic immune stimulating complexes (pluscoms) are particulate antigen delivery systems. pluscoms consist of cationic immunostimulatory complexes (iscoms) derivatives and are able to elicit in vivo t cell responses against an antigen. objective: to evaluate the effects of pluscoms containing leishmaniamajor antigens (sla) on the type of immune response generated in the murine mode...

introduction the extended program of immunization (epi) in iran is started in 1984, and it played an important and effective role in controlling many infectious diseases in community. the objective of this study was to determine the time trends of vaccination coverage by the type of vaccine among children, in the age group of 0-24 months, in iran from the beginning of epi (1984) to 2013. materi...