OBJECTIVES To review the issues that have arisen with the advent of translational research in terms of integration of data and knowledge, and survey current efforts to address these issues. METHODS Using examples form the biomedical literature, we identified new trends in biomedical research and their impact on bioinformatics. We analyzed the requirements for effective knowledge repositories ...

background: in many clinical situations, knowledge of central venous pressure (cvp) is important.  measurement of cvp is not always possible.   objective: to determine if intraocular pressure (iop) can be used as an estimate for cvp.   methods: iop and cvp were measured concurrently in 30 candidates of coronary artery bypass graft surgery.  those with carotid artery or jugular venous diseases a...

The ability to derive predictions for the outcomes of potential actions from observational data is one of the hallmarks of true causal reasoning. We present four learning experiments with deterministic and probabilistic data showing that people indeed make different predictions from causal models, whose parameters were learned in a purely observational learning phase, depending on whether learn...

e-Learning has become a trend in the world nowadays. However, most researches neglect a fundamental issue – the e-Learner’s prior knowledge on which the useful intelligent systems are based. This research employs the e-Learner’s prior knowledge and mines his/her interior desire on appropriate target courses or materials as a part of a personalization process to construct the overall e-Learning ...

Background: In many clinical situations, knowledge of central venous pressure (CVP) is important.  Measurement of CVP is not always possible. Objective: To determine if intraocular pressure (IOP) can be used as an estimate for CVP. Methods: IOP and CVP were measured concurrently in 30 candidates of coronary artery bypass graft surgery.  Those with carotid artery or jugular venous diseases as we...

This work describes a knowledge-guided clustering approach for mineral potential mapping (MPM), by which the optimum number of clusters is derived form a knowledge-driven methodology through a concentration-area (C-A) multifractal analysis. To implement the proposed approach, a case study at the North Narbaghi region in the Saveh, Markazi province of Iran, was investigated to discover porphyry ...

List Accessing Problem is a well studied research problem in the context of linear search. Input to the list accessing problem is an unsorted linear list of distinct elements along with a sequence of requests, where each request is an access operation on an element of the list. A list accessing algorithm reorganizes the list while processing a request sequence on the list in order to minimize t...