Osteosarcoma (osteogenic sarcoma: OS) is the most common primary malignant bone tumor of long bones, whereas primary osteosarcoma of chest wall, especially in sternum, is extremely rare. We report a 57-year-old man with an immobile slow growing mass located in the middle of the sternum. The patient had no significant pain or tenderness and the past medical history was not remarkable. CT-scan sh...

diagnosis of bone tumors is based on careful evaluation of clinical, imaging and a pathologic findings. so the biopsy of bone and soft tissue sarcomas is the final step in evaluation and a fundamental step in the diagnosis of the lesion. it should not be performed as a shortcut to diagnosis (1). the biopsy should be performed in order to confirm the diagnosis and differentiate among few diagnos...

introduction: breast cancers in the early phase frequently undergo distant metastasis and survival of patients is greatly dependent on distant metastasis. the occurrence of micrometastasis has been suggested to relate with prognostic features of breast cancer, such as lymph node metastasis and the presence of vascular invasion. the aim of this study was to examine the presence of keratin-19 mrn...

Background: Limb salvaging surgeries are current surgical treatment of extremity bone sarcomas. Resected bonereplacement consists of two main methods; tumor prosthesis versus structural allograft. Biological reconstruction withan allograft is an economic cheap method in young sarcoma patients, however, the surgeons are more convinced withtumor prosthesis replacement.Methods: We evaluated the sh...

osteosarcoma is a relatively uncommon malignancy however, it is the most common form of primary malignant bone tumors in human. diagnosis and prognosis of patients with osteosarcoma is limited to clinico-radiopathological parameters, whereas molecular markers of tumor aggression have been poorly identified. survivin, an inhibitor of apoptosis (iap), is unique for its expression in human tumors ...

developmental midline perinasal masses in children are rare lesions specifically in association with choristomas. we encountered a 3-year-old boy with epiphora, a striking mass on the nasal bridge and ipsilateral nasal hypoplasia. ct scan imaging showed multiple calcified areas within the tumor in addition to linear defect in frontal bone, hypoplastic left ethmoidal sinus and left nasal cavity,...

Prostate cancer generally metastasizes to bone, and most patients have tumor cells in their bone marrow already at diagnosis. Tumor cells at the metastatic site may therefore progress in parallel with those in the primary tumor. Androgen deprivation therapy is often the first-line treatment for clinically detectable prostate cancer bone metastases. Although the treatment is effective, most meta...

Abstract Bone metastasis is the main cause of death in patients with prostate cancer (PCa), but there lacks effective treatment method. Immunotherapy shows new hopes for bone metastatic PCa patients, while efficacy still unsatisfactory and limited by unique immunosuppressive microenvironment site. Here, we developed a bone-targeted nano-delivery system as nano-regulator to enhance immunotherapy...