The evolutionarily conserved lethal giant larvae (Lgl) tumor suppressor gene has an essential role in establishing apical-basal cell polarity, cell proliferation, differentiation, and tissue organization. However, the precise molecular mechanism by which the Lgl carries out its function remains obscure. In the current study, we have identified Ran-binding protein M (RanBPM) as a novel binding p...

The endocannabinoid 2-arachidonoylglycerol (2-AG) plays a major role in many physiological processes, and its action is quickly terminated via enzymatic hydrolysis catalyzed by monoglyceride lipase (MGL). Regulating its endogenous level could offer therapeutic opportunities; however, few selective MGL inhibitors have been described so far. Here, we describe the synthesis of N-substituted maleim...

An in vitro method was developed for high frequency shoot regeneration and continuous production of Brassica napus L. in large number. The different concentrations of benzyladenine (1.5, 3.0 and 4.5 mgl and thidiazuron (0, 0.15 and 0.30 mgl) were evaluated for shoot and root regeneration using hypocotyl explants with 7, 14 and 21 days old. Shoot regeneration (SR) was affected by both benzyladen...

Abstract Macrophage plasticity and functional activation are critical to the broad array of macrophage-mediated functions that help determine disease outcomes. galactose-type lectin (MGL), a type-2 C-type receptor (CLR) primarily expressed on myeloid cells, has been shown play an anti-inflammatory role in innate response some infectious agents. Our lab recently demonstrated MGL-1 contributes an...

Adult-onset Still's disease (AOSD) is a multisystem inflammatory disease of unknown etiology. It is characterized by arthritis, hectic fever, transient rash and visceral lesions such as pleuropericarditis, lymphadenopathy and hepato splenomegaly. Although kidney involvement may appear in some cases of AOSD, minimal glomerular lesion (MGL) has not been described. We describe a female patient, wh...

C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer. In this review, we focus on the role of the macrophage galactose type C-type lectin (MGL) in the immune response against self-antigens, pathogens, and tumor associated a...