OBJECTIVE To investigate whether the structural connectivity of the brain's rich-club organization is altered in patients with primary progressive MS and whether such changes to this fundamental network feature are associated with disability measures. METHODS We recruited 37 patients with primary progressive MS and 21 healthy controls for an observational cohort study. Structural connectomes ...

Previous research indicates that the motion of the golf club is not planar and that the plane traced out by the club is different than that of the golfer's hands. The aim of the present study was to investigate how the position of the club, relative to the golfer's swing plane, influences the motion of the club by using a four-segment (torso, upper arm, forearm, and club), three-dimensional for...

Recent studies using Magnetic Resonance Imaging (MRI) have proposed that the brain's white matter is organized as a rich club, whereby the most highly connected regions of the brain are also highly connected to each other. Here we use both functional and diffusion-weighted MRI in the human brain to investigate whether the rich club phenomena is present with functional connectivity, and how this...

Breakfast clubs are widely promoted as having a beneficial impact on children's behavior at the start of the school day, which can be conducive to their learning within the classroom. However, the few available studies that have considered the impact of breakfast club attendance on children's behavior have yielded mixed results and no studies to date have directly observed children's behavior w...

Between 1994 and 1997 we used the Ilizarov apparatus to treat 12 recurrent arthrogrypotic club feet in nine patients with a mean age of 5.3 years (3.2 to 7). After a mean of three weeks (two to seven) for correction of the deformity and 1.5 weeks (one to four) for stabilisation in the apparatus, immobilisation in a cast was carried out for a mean of 14 weeks (7 to 24). The mean follow-up period...

Taking up the view that semi-institutional gatherings such as clubs, societies, research schools, have been instrumental in creating sheltered spaces from which many a 20th-century project-driven interdisciplinary research programme could develop and become established within the institutions of science, the paper explores the history of one such gathering from its inception in the early 1980s ...

László Z. Varga Department of Electronic Engineering, Queen Mary and Westfield College, University of London, Mile End Road, London E1 4NS, UK. on leave from: KFKI Research Institute for Measurement and Computing Techniques, Budapest POB 49, 1525 Hungary, OTKA F4064. Nick R. Jennings Department of Electronic Engineering, Queen Mary and Westfield College, University of London, Mile End Road, Lon...

PROLOGUE Clinical toxicology is a topic instructed at some level in most colleges of pharmacy. Traditionally, instruction involves an array of commonly encountered toxic ingestions that might include: acetaminophen, tricyclic antidepressants, and benzodiazepines. Recently, an emerging group of chemicals known as “club drugs” have become increasingly popular substances of abuse. Commonly cited i...