B-acute lymphoblastic leukemia (B-ALL) is the frequent pediatric malignity. Chemotherapy is the most practical approaches to deal with such malignancies. Microtubule-targeted agents are one of the most strategic drugs which formerly use in chemotherapy.Although,colchicine-binding anti-tubulin agents exhibited promising effects in clinical trials, their exact mechanism of action is not fully und...

OBJECTIVE The aim of the study was to test the hypothesis that higher childhood cognitive ability is associated with reduced risk of decline in physical capability in late midlife. METHODS Participants were 1954 men and women from the Medical Research Council National Survey of Health and Development with complete data on cognitive ability at age of 15 years and measures of grip strength and ...

Objectives: Hypertension is a major risk factor for white matter hyperintensities (WMH), lacunes, cerebral microbleeds, and perivascular spaces, which are MRI markers of cerebral small vessel disease (SVD). Studies have shown associations between these individual MRI markers and cognitive functioning and decline. Recently, a "total SVD score" was proposed in which the different MRI markers were...

Decline curve analysis has some advantages over transient well test analysis in which it is not required to shut-in the well and also wellbore storage effects do not exist. Few studies have been done on decline curve analysis of naturally fractured reservoirs but there are even some limitations with available models. On the other hand well test could be expensive and in some operational conditi...

We performed a global assessment of how fish biomass has changed over the last 100 yr, applying a previously developed methodology using ecological modeling. Our assessment built on more than 200 food web models representing marine ecosystems throughout the world covering the period from 1880 to 2007. All models were constructed based on the same approach, and have been previously documented. W...

Many economists argue that high mortality is a major restraint on human capital accumulation and, in turn, growth. A short time horizon makes a person less likely to invest. Therefore, having a lower life expectancy reduces the incentive to obtain schooling. However, there is controversy over whether this theoretical effect is empirically important. Most previous research designs have been unab...

We examine whether the availability of subsidized health insurance to the non-working population in Taiwan affected the labor force participation of married women. Our empirical identification exploits the fact that such insurance was first made available to wives of government employees, before being made universally available in Taiwan in 1995. We find that the availability of insurance for n...