Objective: To assess the rationale for bone marrow biopsy/aspiration as a part of routine systemic workup in advanced intraocular retinoblastoma (RB) relation to high-risk histopathological post-enucleation features. Methods: A retrospective observational study was conducted at Department Pediatric Hematology and Oncology Children’s Hospital, Lahore, Pakistan. Data regarding demographics, clini...

Lymphocyte cultures were employed to assess the degree of spontaneous and induced chromosomal fragility in retinoblastoma. Sister chromatid exchange (SCEs) were scored in metaphases. Three unilateral, three bilateral, eleven family members and controls were studied. Retinoblastoma (RB) lymphocytes did not exhibit increased spontaneous fragility. X-irradiation (25-200 rad) did not significantly ...

PURPOSE To report a case of adult retinoblastoma with a wrong diagnosis of melanoma. CASE REPORT Herein, we present an adult retinoblastoma case who was misdiagnosed as melanoma in fine-needle aspiration biopsy with intravitreal hemorrhage and later neovascular glaucoma after biopsy. The diagnosis of retinoblastoma was confirmed after enucleation. CONCLUSION Retinoblastoma should be conside...

Background and Objectives: One of the relatively modern branches in the knowledge of epidemiology, which despite being very important, very few articles have been published about it so far, is the branch of educational epidemiology. Therefore, the purpose of this study is to introduce the branch of educational epidemiology. Materials and Methods: This study is a comprehensive review study in w...

It has been well known that the survivors of retinoblastoma are prone to have osteosarcoma. But the secondary tumor usually occurs in bilateral, hereditary type of retinoblastoma. We report one case of osteosarcoma in a survivor of unilateral, sporadic retinoblastoma. A fourteen year old male presented with a painfully swollen distal forearm of 2 month duration. He had enucleated his left eye 1...

INTRODUCTION Retinoblastoma is the most common primary intraocular malignancy of childhood. It is usually diagnosed before the age of 5 years. In spite of its early onset in most children, retinoblastoma is rarely diagnosed congenitally or even within the first 3 months of life. OBJECTIVE To report a case of retinoblastoma in early infancy. CASE This was a case of the earliest presentation ...

PURPOSE To determine the types and frequency of ocular conditions simulating retinoblastoma (pseudo-retinoblastoma) at Farabi Eye Hospital, Tehran, Iran. METHODS We reviewed data of patients who were referred with a diagnosis of retinoblastoma to Farabi Eye Hospital oncology clinic, from January 2009 to July 2013. Examination under general anesthesia was performed for all patients. Other inve...

Retinoblastomas result from the inactivation of the RB1 gene and the loss of Rb protein, yet the cell type in which Rb suppresses retinoblastoma and the circuitry that underlies the need for Rb are undefined. Here, we show that retinoblastoma cells express markers of postmitotic cone precursors but not markers of other retinal cell types. We also demonstrate that human cone precursors prominent...

It is hard to believe that as recently as a decade ago, some of us were finding it virtually impossible to get an epidemiologic study funded from the National Cancer Institute if it required collection and analysis of DNA. Now, it is virtually impossible to get anything funded if you do not! The rapid transformation of epidemiology into the molecular world has been so swift and dramatic that by...