A synergistic increase in the cytotoxic effects of recombinant human tumor necrosis factor (TNF-a), interferons (IFN-o, IFN-0, and IFN-7) and heat-stress was demonstrated in vitro. The toxicity of these agents was assessed in the human cervical carcinoma HeLa cell line: the toxic effect was greatly increased when cells pretreated with IFNs or TNF were submitted to a 1-h heat-shock at 45°C. Mor...

cervical cancer is the most common gynecologic cancer and the second most common cancer in women worldwide. herbal preparations are used to treat cancer for centuries. the aim of this study was investigate the cytotoxic effects of the methanol extract of citrullus colocynthis and volatile oils of iranian c. medica on hela cell line. after preparation extract and volatile oils, different concent...

OBJECTIVES The purpose of this study was to evaluate the cytotoxic effect of six dental adhesives (Admira Bond, Clearfil Liner Bond 2V, ED Primer II, Fuji Bond LC, Gluma Comfort Bond, and NanoBond) applied to cell cultures. METHODS The experiments were performed on two cell lines, rat pulp cells (RPC-C2A) and human lung fibroblasts (MRC5). Samples of the adhesives were light-cured and placed ...

Background:  Cotton seed is one of the main sources of protein in animal feeds, containing gossypol, which has been shown to have toxic effects. Results reported by various studies also indicate the anti-cancer effects of gossypol on various cell types. However, its toxic effects on human and animal cells have not been fully established. This study was planned to investigate, for the first time...

Phenolic compounds including flavonoids and phenolic acids are plants secondary metabolites. Due to their ability to act as antioxidant agents, there is a growing interest to use those components in traditional medicine for cancer prevention or treatment. The aim of this study was to measure the amounts of total phenolics and flavonoids as well as anti-proliferative effect of aqueous extract of...

the biological application of nanoparticles (nps) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human cancers. the cytotoxicity was evaluated by mtt and ldh assays. the apoptotic effect of free icd-85 and icd-85 nps on hela cells was assessed using caspase-8 colorimetric assay. the mtt assay showed that icd-85 nps could enhance the in-vitro cyt...

extracts derived from viscum album have been shown to kill cancer cells in vitro. some studies have noted that different species of this plant collected from around the world displayed cytotoxic effects in different extents. in the present study, we evaluated the effects of iranian mistletoe extracts on five cancer cell lines. plants growing on hornbeam tree (carpinus betulus) were collected, a...