نتایج جستجو برای: heroin
تعداد نتایج: 5734 فیلتر نتایج به سال:
An improved synthesis of a haptenic heroin surrogate 1 (6-AmHap) is reported. The intermediate needed for the preparation of 1 was described in the route in the synthesis of 2 (DiAmHap). A scalable procedure was developed to install the C-3 amido group. Using the Boc protectng group in 18 allowed preparation of 1 in an overall yield of 53% from 4 and eliminated the necessity of preparing the di...
There remains debate regarding the impact of cannabis on neuropsychiatric disorders. Here, we examined the effects of cannabidiol (CBD), a nonpsychoactive constituent of cannabis, on heroin self-administration and drug-seeking behavior using an experimental rat model. CBD (5-20 mg/kg) did not alter stable intake of heroin self-administration, extinction behavior, or drug seeking induced by a he...
Introduction & Objectives: The goal of our study was to elucidate the time and factors influencing the transition from non-injection to injection among male heroin users. Materials & Methods: In this retrospective cohort study conducted in Iran from April to August 2007, the data was obtained from the subjects who had never injected heroin at study entry. The total population included 7743 (...
Objectives: This study is carried out with the aim of assessing the relationship between craving and impulsivity factors in three main groups of opiate addicts [heroin, crack-heroin (locally known, purified crystaline heroin), and opium]. Method: 77 opiate users in 3 groups [37 heroin intravenous (IV) abusers, 17 crack smokers and 23 opium smokers] were selected using a semi-structured intervie...
Objective: The aim of current study was to compare the visual memory functions among heroin dependents and normal individuals. Method: The method of current research was causative-comparative carried out on two groups of heroin dependents and normal individuals. Statistical population of the research was people with heroin dependents that from March 2013 to September 2013 that referred to Drug ...
Dopamine receptor stimulation is critical for heroin-conditioned immunomodulation; however, it is unclear whether the ventral tegmental area (VTA) contributes to this phenomenon. Hence, rats received repeated pairings of heroin with placement into a distinct environmental context. At test, they were re-exposed to the previously heroin-paired environment followed by systemic lipopolysaccharide t...
It is well documented that in 2001, the Australian market for illicit drugs experienced a serious disruption to the supply of heroin. This event, colloquially referred to as “the heroin drought” saw a substantial decline in both the availability and purity of heroin, while the price of a gram in Perth rose to $750, rendering it the most expensive market for heroin in Australia at the time. The ...
Opiate withdrawal is followed by a protracted abstinence syndrome consisting of craving and physiological changes. However, few studies have been dedicated to both the characterization and understanding of these long-term alterations in post-dependent subjects. The aim of the present study was to develop an opiate dependence model, which induces long-lasting behavioral changes in abstinent rats...
OBJECTIVE Neuro-electrophysiological tools have been widely used in heroin addiction studies. Previous studies indicated that chronic heroin abuse would result in abnormal functional organization of the brain, while few heroin addiction studies have applied the effective connectivity tool to analyze the brain functional system (BFS) alterations induced by heroin abuse. The present study aims to...
Rats with a previous history of heroin self-administration were studied to assess interactions occurring between cannabinoids and opioids in an animal model of reinstatement of heroin-seeking behaviour. Rats were trained to self-administer heroin and after a long-term extinction were primed with one of the following non-contingent non-reinforced drug administrations: saline (or vehicle), heroin...
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