Background & Objective: Squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer that may be caused by Human papillomavirus (HPV), especially in immunosuppressed patients. However, the role of the mucosal types of HPV in SCC patients with normal immunity has not been extensively confirmed. The aim of this study was to investigate the association...

Background: Detection and quantification of human Papillomavirus (HPV) genome in oral carcinoma play an important role in diagnosis, as well as implications for progression of disease. Methods: We evaluated tissues from 50 esopharyngeal cancers collected from different regions of Iran for HPV E6 using the two type-specific primers sets. E6 gene of HPV genotypes was amplified by specific primers...

Background: Somatic TP53 mutations are frequent in head and neck squamous cell carcinoma (HNSCC) important pathogenic factors. Objective: To study relative to the presence of human papillomavirus (HPV) tumors HNSCC patients. Methods: Using a custom-made next-generation sequencing (NGS) panel on formalin-fixed, paraffin-embedded tumor tissue, we analyzed somatic single-nucleotide polymorphism (S...

Abstract Head and neck squamous cell carcinoma (HNSCC) is amongst the rapidly growing form of cancer associated with high mutation burden Human Papilloma virus (HPV) infection presenting approximately 800,000 new cases 400,000 deaths annually. HPV-positive HNSCC has been strongly better prognosis than HPV-negative due to immune activation in tumor microenvironment including cytotoxic CD8+ T cel...

Objective(s): Valproic acid (VPA) has proven to be as one of the most promising useful drug with anticancer properties.In this study, we investigate the VPA effects on E-cadherin expression in HeLa, TC1, MKN45, and HCT116 cell lines.  This study assesses the effects of VPA on human papillomavirus E7 expression in HPV positive cell lines. Materials and Methods: Cell lines were treated by2 mmol/...

conclusions in this investigation, the prevalence of hpv infection was relatively substantial. totally, 17 different hpv genotypes were detected and the most frequently detected genotypes were hpv6, hpv11, hpv16, hpv18 and hpv52, respectively. the data from this study is essential for planning future public health strategies including hpv vaccination programs. results no statistical association...

Background and Aims: Ovarian cancer is one of most common causes of cancer related women's mortalities. Human papilloma virus is a known factor concerning cervical cancer but its role in causing ovarian cancer is not yet verified. A few studies also identified HPV DNA in ovarian carcinoma tissues. However, some studies did not detect HPV DNA in ovarian carcinoma tissues. In this articl...