Nečas J., L. Bartošíková, T. Florian, J. Klusáková, V. Suchý, E. Janoštíková, T. Bartošík, EM. B. El Naggar: Protective Effects of Flavonoid Pomiferin on Heart IschemiaReperfusion. Acta Vet. Brno 2007, 76: 363-370. The objective of the present 15-day study was to evaluate the cardioprotective potential of fl avonoid pomiferin isolated from the infructences of Maclura pomifera, Moraceae, against...

BACKGROUND The effects of moclobemide on damaged ovarian tissue induced by ischemia- reperfusion and damaged contralateral ovarian tissue were investigated in rats, biochemically and histologically. MATERIALS AND METHODS In this experimental study, 40 rats were equally divided into four groups: 10 mg/kg moclobemide, 20 mg/kg moclobemide, ischemia/reperfusion control, and intact control groups...

Introduction: Cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. The aim of the present study was to evaluate oxytocin (OT) induced cardioprotection and its signaling pathways on lactate dehydrogenase (LDH) and creatine kinase-MB isoenzyme (CK-MB) in the anesthetized rats. Methods: Ei...

introduction: cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. the aim of the present study was to evaluate oxytocin (ot) induced cardioprotection and its signaling pathways on lactate dehydrogenase (ldh) and creatine kinase-mb isoenzyme (ck-mb) in the anesthetized rats. methods: eighty...

Background and purpose Little is known about post-ischemic blood-cerebrospinal fluid (CSF) disruption. The source of CSF, choroid plexi, are selectively vulnerable to cerebral ischemia (1). This was previously addressed only in one experimental study by means of magnetic resonance imaging (MRI) (2). Evaluating past contrast-enhanced MRI studies executed in the acute phase of stroke, we noticed ...

Preeclampsia is a severe disorder of human pregnancy characterized by generalized activation of maternal endothelial cells. Oxidative stress of the placenta is considered a key intermediary step, precipitating deportation of apoptotic fragments into the maternal circulation, but the cause remains unknown. We hypothesize that intermittent placental perfusion, secondary to deficient trophoblast i...

Porter GA, Urciuoli WR, Brookes PS, Nadtochiy SM. SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts. Am J Physiol Heart Circ Physiol 306: H1602–H1609, 2014. First published April 18, 2014; doi:10.1152/ajpheart.00027.2014.—Ischemiareperfusion (IR) injury is significantly worse in aged hearts, but the underlying mechanisms are poorly understood. Age-related dam...

OBJECTIVES : Pulmonary edema has been shown to occur following ischemiareperfusion injury in a variety of organs and effects of several pharmacological agents on ischemia-reperfusion-induced damage has been investigated previously. However, there are only a few studies in the literature about pulmonary injury following adnexial ischemia-reperfusion. In this study we aimed at investigating pulmo...

Xu Z, Prathapasinghe G, Wu N, Hwang SY, Siow YL, O K. Ischemia-reperfusion reduces cystathionine-synthase-mediated hydrogen sulfide generation in the kidney. Am J Physiol Renal Physiol 297: F27–F35, 2009. First published May 13, 2009; doi:10.1152/ajprenal.00096.2009.—Cystathionine-synthase (CBS) catalyzes the rate-limiting step in the transsulfuration pathway for the metabolism of homocysteine ...

Sambandam, Nandakumar, Dominique Morabito, Cory Wagg, Brian N. Finck, Daniel P. Kelly, and Gary D. Lopaschuk. Chronic activation of PPAR is detrimental to cardiac recovery after ischemia. Am J Physiol Heart Circ Physiol 290: H87–H95, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00285.2005.— High fatty acid oxidation (FAO) rates contribute to ischemia-reperfusion injury of the m...