نتایج جستجو برای: liver kidney microsome antibody
تعداد نتایج: 668747 فیلتر نتایج به سال:
The aim of this study was to evaluate the (3S)-3-hydroxylation and the N-oxidation of quinidine as biomarkers for cytochrome P-450 (CYP)3A4 activity in human liver microsome preparations. An HPLC method was developed to assay the metabolites (3S)-3-hydroxyquinidine (3-OH-Q) and quinidine N-oxide (Q-N-OX) formed during incubation with microsomes from human liver and from Saccharomyces cerevisiae...
Background and Objective: Diazinon (DZN) as an organophosphate (OP) pesticide induces the production of free radicals and oxidative stress. The aim of this study was to investigate the effect of N-acetyl cysteine (NAC) as a n antioxidant against DZN- induced oxidative stress in rat liver and kidney. Materials and Methods: In the present experimental study , male Wistar rats were randomly di...
We describe here a decrease in the ratio of phospholipids to protein in microsomes prepared from Morris hepatoma 7777, compared with those from host rat liver. These micro somes, characterized by their marker enzyme content, were found to have comparable enrichment of the NADPH cytochrome c reducÃ-ase. In addition to the decrease in phospholipid content, the major phospholipids had decreased po...
background: cadmium (cd) is not considered as essential element for living organisms, therefore its presence in tissues is considered as toxic element. from food hazards control point of view, information on the distribution of these toxic elements in the animal tissues is very important. the present study was designed to evaluate cd distribution pattern in kidney and liver of broiler chicken. ...
No therapies have been shown to accelerate recovery or prevent fibrosis after acute kidney injury (AKI). In part, this is because most therapeutic candidates have to be given at the time of injury and the diagnosis of AKI is usually made too late for drugs to be efficacious. Strategies to enhance post-AKI repair represent an attractive approach to address this. Using a phenotypic screen in zebr...
Objective(s): Populus species have various pharmacological properties, including antioxidant activity. In this study, the effects of Populus tomentiglandulosa extract (PTE) on histopathology and antioxidant enzymes in the rat liver and kidney were examined. Materials and Methods: Sprague-Dawley rats were assigned to three groups; (1) no...
Abstract Background and purpose: Methotrexate as a chemotherapy drug causes chronic liver damage, infiltration of neutrophils, oxidative stress, and direct renal tubular damage. Quercetin is a flavonoid with antioxidant and anti-inflammatory properties. Therefore, the aim of this study was to investigate the effect of quercetin on eliminating the liver and kidney toxicity of methotrexate. M...
Background & Objectives: Respiratory, central nervous system, and skin complications of mustard gas toxicity have previously been studied; however, the liver and kidney side effects due to this intoxication have not been fully noted. We aimed to evaluate the frequency of liver, kidney and lung lesions in mustard gas-exposed Iranian veterans who had been exposed to the toxin almost 2 decades bef...
Background: Cadmium (Cd) is not considered as essential element for living organisms, therefore its presence in tissues is considered as toxic element. From food hazards control point of view, information on the distribution of these toxic elements in the animal tissues is very important. The present study was designed to evaluate Cd distribution pattern in kidney and liver of broiler chicken. ...
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