Chronic metabolic acidosis has been previously shown to stimulate protein degradation. To evaluate the effects of chronic metabolic acidosis on nitrogen balance and protein synthesis we measured albumin synthesis rates and urinary nitrogen excretion in eight male subjects on a constant metabolic diet before and during two different degrees of chronic metabolic acidosis (NH4Cl 2.1 mmol/kg body w...

Hypoventilation, associated with hypercapnic acidosis (HCA), may improve outcome in acute lung injury (ALI). We have recently reported that HCA per se protects against ALI. The current study explored whether the mechanisms of protection with HCA were related to acidosis versus hypercapnia. Because CO(2) equilibrates rapidly across cell membranes, we hypothesized that (1) HCA would afford greate...

Fluid resuscitation lies at the heart of acute care medicine. Despite the central role occupied by plasma volume expansion therapeutics, there remains little consensus regarding the ideal fluid for plasma volume expansion. However, the unintended consequences of excessive plasma volume expansion as well as those untoward events directly ascribed to the prescribed fluids have come to the fore. A...

Provision of AA has shown success in attenuating proteolytic activity in monogastrics suffering from metabolic acidosis. However, it is unknown whether AA supplementation can provide any beneficial effects to ruminants with nutritionally induced metabolic acidosis. The objective of the current study was to examine the effects of glutamine infusion on various protein degradation components acros...

Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes of cancer cells. We compared global transcriptional responses of breast cancer cells in response to three distinct tumor microenvironmental stresses: lactic acidosis, glucose deprivation, and hypoxia. We found that lactic...

metabolic alkalosis is characterized by high hco3- as it is seen in chronic respiratory acidosis, but ph differentiates the two disorders. there is no characteristic symptom or sign. orthostatic hypotension may be encountered. weakness and hyporeflexia occur if serum k+ is markerdly low. tetany and neuromuscular irritability occur rarely. we report the results of retrospective data analysis of ...

Objective: To determine how the balance between mineral base, and carbonic and organic acids is altered to cause metabolic acidosis in preterm infants. Study Design: Mineral balance and arterial blood measurements of 3 groups of preterm infants given 5 different Total Parenteral Nutrition (TPN) regimens were analyzed. Mineral base was measured as the difference between mineral cations and anion...