objective(s):n-myc downstream regulated gene 2 (ndrg2) is a candidate gene for tumor suppression. the expression of ndrg2 is down-regulated in several tumors including lung cancer. the aim of this study was to explore the effect of ndrg2 overexpression on invasion, migration, and enzymatic activity of matrix metalloproteinase-2 (mmp-2) and -9 (mmp-9) in human lung adenocarcinoma a549 cells.  ma...

The recurrence rate in patients who undergo surgery for abdominal wall hernias (AWHs) is high. AWHs have been hypothesized to be a disease of the extracellular matrix, which supported by evidence showing high incidence with connective tissue disorders. This study aimed investigate most recent literature studies describing levels several matrix metalloproteinases (MMPs) blood and fascia, objecti...

background serum apoptotic cytokeratine 18 neoepitope m30 (ck-18 m30) and matrix metalloproteinase 2 (mmp-2) have been popular markers for detecting liver fibrosis in recent years. ck-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apoptosis. mmp-2 plays an important role in tissue remodeling and repairing process...

Background: The aim of the study was to longitudinally evaluate association between MMP-2, MMP-9, TIMP-1 and chest radiological findings in COVID-19 patients. Methods: patients were evaluated based on their hospital admission (baseline) three months after discharge (T post) stratified into ARDS non-ARDS groups. As a control group, healthy donors (HD) enrolled. Results: At baseline, compared HD ...

Objective. The ubiquitin-like with PHD and ring finger domains 1 (UHRF1) is a protein coding gene which associated colorectal cancer other diseases. Therefore, the present study was aimed at investigating effect mechanism of UHRF1 on invasion metastasis in human renal carcinoma cells. Methods. After interfered or overexpressed cell lines A498 769-P, relative mRNA level detected by RT-qPCR immun...

Objective(s):N-myc downstream regulated gene 2 (NDRG2) is a candidate gene for tumor suppression. The expression of NDRG2 is down-regulated in several tumors including lung cancer. The aim of this study was to explore the effect of NDRG2 overexpression on invasion, migration, and enzymatic activity of matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) in human lung adenocarcinoma A549 cells.  Ma...

Background: Numerous experiments have been performed to determine the relationship between the Matrix metalloproteinase-2 (MMP-2) -1306C/T and -735C/T polymorphisms and the prevalence and progression of lung cancer in diverse populations. However, due to the small sample size and the different results of previous studies, we decided to perform a general meta-analysis on all previous studies abo...