OBJECTIVE The principal objective of this investigation was to identify novel cytokine associations with BMI and type 2 diabetes (T2D). METHODS Cytokines were profiled from African American women with obesity who donated plasma to the Komen Tissue Bank. Multiplex bead arrays of analytes were used to quantify 88 cytokines and chemokines in association with clinical diagnoses of metabolic healt...

The response regulator VirR and its cognate sensor histidine kinase, VirS, are responsible for toxin gene regulation in the human pathogen Clostridium perfringens. The C-terminal domain of VirR (VirRc) contains the functional FxRxHrS motif, which is involved in DNA binding and is conserved in many regulatory proteins. VirRc was cloned, purified, and shown by in vivo and in vitro studies to comp...

Bitcoin exchanges operate between digital and fiat currency networks, thus providing an opportunity to connect real-world identities to pseudonymous addresses, an important task for anti-money laundering efforts. We seek to characterize, understand, and identify patterns centered around exchanges in the context of a directed hypergraph model for Bitcoin transactions. We introduce the idea of mo...

le missionnaire est un voyageur particulier qui voyage pour un motif sublime: celui de la propagande du christianisme. les missionnaires ne sont pas très nombreux, mais, ils ont écrit bien de livres par lesquels nous pouvons tracer leur démarche à travers l’asie et la perse en particulier. cet article est consacré à l’étude et l’analyse de cette mission tout d’abord en asie et plus particulière...

Bacteriorhodopsin, the photosynthetic protein of Halobacterium salinarum, is optimally expressed under anaerobic growth conditions. We identified Brz (OE3104F, bacteriorhodopsin-regulating zinc finger protein), a new regulator of the bop gene. It is a small protein with a zinc finger motif, encoded directly upstream of the bop gene in the same orientation. Deletion of the brz gene caused a larg...

Background: The 2 50 k Da r etinoblastoma bi nding pr otein 6 (RBBP6) was cloned over a decade ago and was found to bind both the p53 and Rb1 tumor s uppressor proteins. In a ddition, R BBP6 has be en a ssociated with multiple b iological f unctions, s uch a s m itosis, m RNA p rocessing, tr anslation and ubiquitination. Objectives: In the current study, an in silico approach was used to identi...

Treponema pallidum, the causative agent of syphilis, is a highly invasive pathogenic spirochete capable of attaching to host cells, invading the tissue barrier, and undergoing rapid widespread dissemination via the circulatory system. The T. pallidum adhesin Tp0751 was previously shown to bind laminin, the most abundant component of the basement membrane, suggesting a role for this adhesin in h...

Contemporary high-throughput technologies permit the rapid identification of transcription factor (TF) target genes on a genome-wide scale, yet the functional significance of TFs requires knowledge of target gene expression patterns, cooperating TFs, and cis-regulatory element (CRE) structures. Here we investigated the myogenic regulatory network downstream of the Drosophila zinc finger TF Lame...