The thalamic ventral posterior lateral neurons (VPL) respond to somatosensory stimulation with a burst of action potentials followed by a periodic oscillation at the spindle frequency. This study aims to build a statistical model to quantify the multi -unit behavior and explain putative underlying mechanisms. Multi -unit data, comprising 4 or 5 different neurons, were collected from anesthetize...

Motivated by features of low latency data in finance we study in detail discrete-valued Lévy processes as the basis of price processes for high frequency econometrics. An important case of this is a Skellam process, which is the difference of two independent Poisson processes. We propose a natural generalisation which is the difference of two negative binomial processes. We apply these models i...

background: malaria is a major cause of morbidity and mortality in nepal. the magnitude of malaria across the country is alarming and varies with location. therefore, the present study aimed to model malaria incidence rates during 1998 to 2009 in nepal. methods: data for the study were obtained from health management information system (hmis), ministry of public health. a negative binomial mode...

Micro-array protein crystal images are now routinely acquired automatically by CCD cameras. High-throughput automatic classification of protein crystals requires to alleviation of the time-consuming task of manual visual inspection. We propose a classification framework combined with a multi-scale image processing method for recognizing protein crystals and precipitates versus clear drops. The ...

We derive analytically the solution for the output rate of the ideal coincidence detector. The solution is for an arbitrary number of input spike trains with identical binomial count distributions (which includes Poisson statistics as a special case) and identical arbitrary pairwise cross-correlations, from zero correlation (independent processes) to complete correlation (identical processes).

The central part of pricing agricultural commodity futures options is to find appropriate stochastic process of the underlying assets. The Black’s (1976) futures option pricing model laid the foundation for a new era of futures option valuation theory. The geometric Brownian motion assumption girding the Black’s model, however, has been regarded as unrealistic in numerous empirical studies. Opt...

The beta-binomial distribution is resulted when the probability of success per trial in the binomial distribution varies in successive trials and the mixing distribution is from the beta family. For experiments with binary outcomes, often it may happen that observations exhibit some extra binomial variation and occur in clusters. In such experiments the beta-binomial distribution can generally ...

The present article discusses and presents a new and comprehensive approachaimed at measuring the maturity and quality of software processes. This method has beendesigned on the basis of the Software Capability Maturity Model (SW-CMM) and theMulti-level Fuzzy Inference Model and is used as a measurement and analysis tool. Among themost important characteristics of this method one can mention si...

Heretofore, automatic checkpointing at procedure-call boundaries [1], to reduce the space complexity of reverse mode, has been provided by systems like Tapenade [2]. However, binomial checkpointing, or treeverse [3], has only been provided in AD systems in special cases, e.g., through user-provided pragmas on DO loops in Tapenade, or as the nested taping mechanism in adol-c for time integration...