Abstract A dataset of (E)-N’-benzylideneisonicotinohydrazide derivatives as a potent anti-mycobacterium tuberculosis has been investigated utilizing Quantitative Structure-Activity Relationship (QSAR) techniques. Genetic Function Algorithm (GFA) and Multiple Linear Regression Analysis (MLRA) were used to select the descriptors and to generate the correlation QSAR models that relate the Mi...

Drug resistance (especially multiple drug resistance) in Mycobacterium tuberculosis makes global concerns in treatment and control of tuberculosis. Rapid diagnosis of drug resistant strains of the bacteria has vital importance in the prognosis of the disease. The aim of this study was to identify the mutations responsible for drug resistance in Mycobacterium tuberculosis strains derived from pa...

conclusions results of the current study showed the high prevalence of m. tuberculosis among the patients with lung cancer; therefore, it seems that continuous surveillance is essential to monitor the m. tuberculosis in the patients with lung cancer. results the subjects included 252 (66.3%) males and 128 (33.7%) females. based on cultural and microscopic methods, m. tuberculosis infection was ...

discussion transthoracic echocardiography disclosed massive pericardial effusion, respiratory variation in mitral and tricuspid inflow e velocity, increased diastolic flow reversal with expiration in the hepatic vein, septum deviation in inspiration toward the left ventricle (lv), preserved lv function, and inferior vena caval (ivc) dilation without any collapse in inspiration. chest computed t...

background: tuberculosis (tb) remains as a major cause of death around the world. construction of a new vaccine against tuberculosis is an effective way to control it. several vaccines against this disease have been developed. the aim of the present study was to cloning of tb10.4 gene in pcdna3.1+ plasmid and evaluation of its expression in eukaryotic cells. methods: firstly, tb10.4 fragment wa...

background: the risk of developing tuberculosis is high among chronic hemodialysis patients. the tuberculin skin test (tst) has been in use for diagnosing latent tb, but few data are available on tst in hemodialysis patients. objective: this study was done to identify the tst reactivity and frequency of booster effect in serial tst among hemodialysis patients. methods: a total of 100 patients i...