During pregnancy, maternal and fetal Ca demands are met through increased intestinal Ca absorption. Increased Ca absorption may be more dependent on oestrogen’s up-regulation of Ca transport genes than on vitamin D status. Numerous studies, however, have found that severe vitamin D deficiency with secondary hyperparathyroidism during pregnancy leads to abnormal Ca homoeostasis in the neonate. S...

ITE JOURNAL / AUGUST 2001 BACKGROUND High speeds and rapidly increasing vehicle volumes characterize many of America’s rural, two-lane highways. These features, combined with midto shortradius horizontal curves and limited sight distances, can create hazardous road conditions for the motoring public. These highways may or may not exhibit high accident numbers or rates but are often described by...