Progressive Supranuclear Palsy (PSP) is an atypical Parkinsonism noted for postural instability, early falls, and a supranuclear vertical gaze palsy. However, since its original description, several variants were described. One of the rarer variants is PSP-C, further adding to the diverse clinical. As a result, misdiagnosis of PSP-C as multiple system atrophy, or a spinocerebellar degeneration ...

We examine the conditions under which spike-timing-dependent plasticity (STDP) normalizes post-synaptic 0ring rates. Our simulations show that the rate normalization property of STDP is fragile and small changes in the LTD=LTP ratio or pre-synaptic input rates can lead to high 0ring rates. We propose an adaptive scheme to dynamically control the LTP=LTD ratio. The biophysics of synapses lead us...

In this article we discuss the short-term synaptic depression using a mathematical model. We derive the model of synaptic depression caused by the depletion of synaptic vesicles for the case of infinitely short stimulation time and show that the analytical formulas for the postsynaptic potential (PSP) and kinetic functions take simple closed form. A solution in this form allows an analysis of t...

BACKGROUND Chemoradiation (CRT) can significantly modify the radiographic appearance of malignant gliomas, especially within the immediate post-CRT period. Pseudoprogression (PsP) is an increasingly recognized phenomenon in this setting, and is thought to be secondary to increased permeability as a byproduct of the complex process of radiation-induced tissue injury, possibly enhanced by temozol...

objectives: this study sought to assess the diagnostic accuracy of cone beam computed tomography (cbct) with different voxel sizes and intraoral digital radiography with photostimulable phosphor (psp) plate for detection of periapical (pa) bone lesions. materials and methods: in this ex vivo diagnostic study, one-millimeter defects were created in the alveolar sockets of 15 bone blocks, each wi...

Background: Evidences show that parental morphine addiction impairs CNS development, learning and memory in offsprings. Since long term potentiation (LTP) is a cellular mechanism of learning and memory, in this study the effect of parental morphine addiction on LTP induction in dentate gyrus by high frequency stimulation of perforant path was assessed. Materials and methods: In this experiment...

ÐThe Personal Software Process is a process improvement methodology aimed at individual software engineers. It claims to improve software quality (in particular defect content), effort estimation capability, and process adaptation and improvement capabilities. We have tested some of these claims in an experiment comparing the performance of participants who had just previously received a PSP co...

systems rehabilitation steps on the strain and temperature rise on apical and cervical root dentin regions. Twenty-one extracted human canine teeth had two strain gages attached to the distal root surface and two thermocouples attached to the mesial root surface (cervical and apical). The strain and temperature rise were recorded during the following procedures: root canal preparation, final ri...

Introduction: The effects of cannabinoids (CBs) on synaptic plasticity of hippocampal dentate gyrus neurons have been shown in numerous studies. However, the effect of repeated exposure to cannabinoids on hippocampal function is not fully understood. In this study, using field potential recording, we investigated the effect of repeated administration of the nonselective CB receptor agonist WIN5...