Tumor necrosis factor (TNF) is known to be a mediator of a variety of cellular responses including apoptotic death or proliferation depending on the target cell and the environmental conditions. We show here that TNF triggers both growth and death signals in NIH 3T3 murine fibroblasts. In cells arrested in G(0) by serum deprivation, TNF drives approximately 50% of them to enter the cell cycle, ...

Thoracic ossification of the ligamentum flavum (TOLF) is characterized by ectopic bone formation in the ligamentum flavum and is considered to be a leading cause of thoracic spinal canal stenosis and myelopathy. However, the underlying etiology is not well understood. An iTRAQ proteomics was used to reveal the involvement of inflammation factors in TOLF. TNF-α is a pro-inflammatory cytokine imp...

It seems that rapid destruction of gram negative bacteria by antibiotics contributes to the clinical deterioration of some patients with gram negative infections. Antibiotics increase the concentration of lipopolysaccharide (LPS) in blood and cerebrospinal fluids. Released LPS can activate blood cells to produce tumor necrosis factor-alpha (TNF-a) and other cytokines. TNF-a appears to be a ...

Many species of tea (Camellia sinensis) and cowslip (Echium amoenum) are used in Iranian traditional medicine. The aim of this study was to conduct the survey on the ability of Iranian black tea and cowslip extracts on secretion of tumor necrosis factor-alpha (TNF-alpha) by non-infected and infected mouse macrophages. A macrophage infection model with Legionella pneumophila and enzyme linked im...

Objective(s): The present study sought to evaluate the beneficial effects of histidine (His) on oxidative stress, tumor necrosis factor alpha (TNF-α), renal histological alterations and anti-oxidant enzymes gene expressions in type 2 diabetic rats.Materials and Methods: Streptozotocin/nicotinamide (STZ/NA) induced diabetic rats were used...

Staphylococcus aureus infections are an important public health concern due to their increasing incidence and high rates of mortality. The success of S. aureus as a pathogen is highly related to its enormous capacity to evade the host immune response. The critical role of tumor necrosis factor alpha (TNF-α) in the initial host defense against systemic staphylococcal infection has been demonstra...

Staphylococcus aureus is the leading cause of skin and soft tissue infections has become a major health burden due to emergence antibiotic-resistant strains. Tumor necrosis factor (TNF) proinflammatory cytokine that rapidly induced upon S. exposure whose inhibition associated with increased risk in humans. However, contribution TNF cognate receptors, TNFR1 TNFR2, host defense against unclear. T...

it seems that rapid destruction of gram negative bacteria by antibiotics contributes to the clinical deterioration of some patients with gram negative infections. antibiotics increase the concentration of lipopolysaccharide (lps) in blood and cerebrospinal fluids. released lps can activate blood cells to produce tumor necrosis factor-alpha (tnf-a) and other cytokines. tnf-a appears to be a majo...