نتایج جستجو برای: therapeutic vaccine
تعداد نتایج: 455626 فیلتر نتایج به سال:
Purpose:Due to the many similarities with its human counterpart, canine malignant melanoma (cMM) is a valuablemodel inwhich to assess the efficacy of novel therapeutic strategies. Themodel is herein used to evaluate the immunogenicity, safety, and therapeutic efficacy of a human chondroitin sulfate proteoglycan4 (hCSPG4) DNA-based vaccine. The fact that homology between hCSPG4 and cCSPG4 amino-...
Previously, our lab was the first to report the use of antigen-sensitized dendritic cells as a vaccine against Alzheimer's disease (AD). In preparation of this vaccine, we sensitized the isolated dendritic cells ex vivo with Aβ peptide, and administered these sensitized dendritic cells as a therapeutic agent. This form of cell therapy has had success in preventing and/or slowing the rate of cog...
OBJECTIVES According to historical medical reports, many children with measles subsequently contracted pertussis, often with fatal results. The likelihood of a child contracting pertussis after a measles infection is increased by its immune-suppressing effects. This research aims to verify the historical reports. METHODS The analysis examines statistically the historical relationship between ...
introduction: addiction is a habit or behavior that is often hard to quit. it is estimated that 190 million persons are substance users around the world. substance abuse creates tolerance after a while. shortly after taking the drug, a person will not enjoy as the beginning of its use that is why the amount of substance used is gradually increased. the purpose of this study was to find the reas...
Most of the therapeutic strategies to control multiple sclerosis are directed to immune modulation and inflammation control. As heat shock proteins are able to induce immunoregulatory T cells, we investigated the therapeutic effect of a genetic vaccine containing the mycobacterial hsp65 gene on experimental autoimmune encephalomyelitis (EAE). Although pVAXhsp65 was immunogenic for mice with EAE...
Therapeutic vaccine candidates against hepatitis C virus infection have demonstrated immunogenicity, but none of them have been able to induce complete viral elimination. Reviewed evidence shows hepatitis C virus-specific T cell exhaustion as a major obstacle for the immune containment of the virus. The possibility that hepatitis C virus-specific T cells may be rescued from exhaustion by interf...
Background: Human colorectal cancer cells overexpress carcinoembryonic antigen (CEA). CEA is a glycoprotein which has shown to be a promising vaccine target for immunotherapy against colorectal cancer. Objective: To design a DNA vaccine harboring CEA antigen and evaluate its effect on inducing immunity against colorectal cancer cells in tumor bearing mice. <str...
Background and purpose: Protecting healthcare workers on the front line of Coronavirus disease 2019 (COVID-19) is very important. The aim of this study was to investigate the incidence of COVID-19 in hospital staff and its relationship with influenza vaccine in 2020. Materials and methods: A descriptive-analytical study was performed in 4446 staff working in public hospitals in Mazandaran prov...
HPVs (Human Papilloma virus) are associated with a variety of clinical conditions that ranges from less harmful lesions to life threatening cancer. During the onset of 19th century, HPV association with human cancers has been found with major links to genital warts and cervical cancers [1]. With recent advances in HPV vaccine, the possibility of preventing the second most common cancer among th...
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