Digitization causes fundamental shifts in economy and society. These changes will go in line with significant changes of corporate core competencies as well as the skills and capabilities of employees. Due to the increasing pace of technological development in production and service processes as well as the ongoing trend to automation classic educational approaches will no longer suffice to ens...

In this study, our objective is to evaluate the potential of a novel Sorafenib derivative, named HLC-080, as a new anticancer agent for colon cancer. We firstly carried out MTT assay, colony formation assay, flow cytometry analysis and transwell invasion assay to determine effect of our compound HLC-080 on cell viability, anti-proliferation activity, cell cycle arrest and the intervention on ce...

This paper describes an experiment to explore the effects of the TENCompetence infrastructure for supporting lifelong competence development which is now in development. This infrastructure provides structured, multi-leveled access to learning materials, based upon competences. People can follow their own learning path, supported by a listing of competences and their components, by competence d...

BACKGROUND Treating symptoms and preventing exacerbations are key components of chronic obstructive pulmonary disease (COPD) long-term management. Recently, a more tailored treatment approach has been proposed, in particular for two well-established clinical phenotypes, frequent exacerbators and chronic bronchitis-dominant COPD. ELOM-080 has demonstrated clinical efficacy in treating symptoms a...

RY-080 (ethyl 8-ethynyl-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate) is an imidazobenzodiazepine with 40–50-fold higher affinity for the benzodiazepine binding site of α5rather than α1-, α2or α3-containing GABAA receptors. Previous data describing RY-080 as being convulsant suggests that inverse agonists selective for the α5 subtype may not be suitable for clin...

We present results from multi-epoch spectral analysis of XMM-Newton and Chandra observations of the mini broad absorption line (BAL) quasar PG 1115+080. This is one of the few X-ray detected mini-BAL quasars to date that is bright enough in the X-ray band, mostly due to large gravitationallensing magnifications, to allow in-depth spectral analysis. The present XMM-Newton observations of PG 1115...

Address for correspondence: Prof. Luigi Macchia MD, PhD, Department and School of Allergology and Clinical Immunology, University of Bari – Aldo Moro, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy, phone: +39 080 5478817, fax: +39 080 5593688, e-mail: [email protected] Received: 30.01.2014, accepted: 29.04.2014 Long-term treatment of refractory severe chronic urticaria by omalizumab...