Rising postglacial seas have flooded the world’s continental shelves, limiting our ability to reconstruct human migrations, the history of settlement along Pleistocene coastlines, and the antiquity of coastal shell middens. This includes the southern coast of Beringia, where dramatic landscape changes make it difficult to test the coastal migration theory, which proposes that Upper Paleolithic ...

Causes of late Quaternary extinctions of large mammals ("megafauna") continue to be debated, especially for continental losses, because spatial and temporal patterns of extinction are poorly known. Accurate latest appearance dates (LADs) for such taxa are critical for interpreting the process of extinction. The extinction of woolly mammoth and horse in northwestern North America is currently pl...

The paleoclimatic history of a region can be viewed as a series of surface temperature and moisture anomalies through time. The e!ects of changes in large-scale climatic controls (e.g., insolation, major circulation controls) can be mediated by the in#uence of smaller-scale controls (e.g., topographic barriers, coastlines); this may result in heterogenous surface climatic responses at the regio...

Disinhibition is a cardinal feature of the behavioural variant of frontotemporal dementia, presenting as impulsive and impetuous behaviours that are often difficult to manage. The options for symptomatic treatments are limited, but a potential target for therapy is the restoration of serotonergic function, which is both deficient in behavioural variant frontotemporal dementia and closely associ...

Prediction of human pharmacokinetics of new drugs, as well as other disposition attributes, has become a routine practice in drug research and development. Prior to the 1990s, drug disposition science was used in a mostly descriptive manner in the drug development phase. With the advent of in vitro methods and availability of human-derived reagents for in vitro studies, drugdisposition scientis...