Objective(s): MicroRNAs (miRNAs) could regulate many cellular processes such as proliferation and differentiation. let-7a miRNA is one of the key regulators in the developmental transition of retinal progenitor cells into differentiated cells. Current evidence suggests that mesenchymal stem cells (MSCs) can isolate from various tissues such as bone marrow and conjuncti...

in this present study, we examined the differentiation potential of human bone marrow derived mesenchymal stem cells (hbmscs) into hepatocytes on a three-dimentional (3d) nanofibrous scaffold formed by poly (ε-caprolactone) (pcl), collagen and polyethersulfone (pes). the nanofiber was prepared by the electrospining technique. hbmscs were isolated using combining gradient density centrifugation ...

MicroRNAs (miRNAs) are short non-coding RNAs involved in post-trascriptional regulation of gene expression and diverse biological activities. They are crucial for self-renewal and behavior of embryonic stem cells, but their role in mesenchymal stem cells has been poorly understood. Recently emerging evidence suggests that miRNAs are closely involved in controlling key steps of mesenchymal stem ...

MicroRNAs (miRNAs) regulate cell proliferation and differentiation by silencing gene expression at the post-transcriptional level; moreover, by binding to the complementary sequences within mRNAs in cancer cells, these small non-coding RNA molecules can function as tumor suppressors or oncogenes. Recently, the dysregulation of miRNA expression has been found to be associated with increased tumo...

objective: bone marrow mesenchymal stem cells reside in bone marrow and support homing and differentiation of hematopoietic stem cells (1). this makes them an excellent instrument for regenerative treatment and co-culture with the hsc. materials and methods: in this study, k562 cell lines were treated with butyric acid(for erythroid differentiation), co-cultured with mesenchymal stem cells and ...

  Objective(s): Erythropoiesis is regulated by some extrinsic and intrinsic factors as microRNAs (miRNAs). miRNAs are endogenously small non-coding regulatory RNAs which play vital roles in the variety of cellular fate, critical processes; growth, apoptosis, metabolism, survival of the cells and specially differentiation. Several miRNAs such as miR-16 and miR-451 have been shown to be correlate...

mesenchymal stem cells (mscs) have the ability to differentiate into neuronal like cells under appropriate culture condition. in this study, we investigated whether mscs derived from human peripheral blood (pb-mscs) can differentiate into neuronal like cells by synergic effect of the growth factors egf, bfgf and noggin. for this purpose, the expression of five neuronal markers (nestin, β iii tu...

multiple sclerosis (ms) is an autoimmune inflammatory demyelinating disease of the central nervous system. the aim of this study was to investigate the neuroprotective effects of transplanted human umbilical cord blood mesenchymal stromal cells (ucb-msc) derived neural progenitor cell (mdnpc) in eae, an experimental model of ms. to initiate neuronal differentiation of ucb-mscs, the pre-inductio...