نتایج جستجو برای: CYP2C19

تعداد نتایج: 1973  

Journal: :Clinical Pharmacology & Therapeutics 2020
Mariana R.Botton, MichelleWhirl‐Carrillo, Andria L.Del Tredici, KatrinSangkuhl, Larisa H.Cavallari, José A. G.Agúndez, JorgeDuconge, Ming Ta MichaelLee, Erica L.Woodahl, KarlaClaudio‐Campos, Ann K.Daly, Teri E.Klein, Victoria M.Pratt, Stuart A.Scott, AndreaGaedigk,

Background: Cytochrome P450 2C19 (CYP2C19) is a polymorphically expressed enzyme that shows marked interindividual and interethnic variation. CYP2C19*2 and CYP2C19*3 are the most frequently identified defective alleles in Orientals and Caucasian poor metabolizers (PM). The aim of this study was to investigate the frequencies of CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles and CYP2C19 genotypes in...

Journal: :Journal of Gastroenterology and Hepatology 2008
Bor-ShyangSheu, Kwong-MingFock,

Journal: :World Journal of Gastroenterology 2014
Chao-HungKuo, Chien-YuLu, Hsiang-YaoShih, Chung-JungLiu, Meng-ChiehWu, Huang-MingHu, Wen-HungHsu, Fang-JungYu, Deng-ChyangWu, Fu-ChenKuo,

Journal: :British Journal of Clinical Pharmacology 2010
AlainLi-Wan-Po, ThierryGirard, PeterFarndon, CandyCooley, JamesLithgow,

Journal: :Journal of the American College of Cardiology 2016
DirkSibbing, LisaGross, SteffenMassberg,

Journal: :The Journal of pharmacology and experimental therapeutics 1998
G C Ibeanu, J A Goldstein, U Meyer, S Benhamou, C Bouchardy, P Dayer, B I Ghanayem, J Blaisdell,

A genetic polymorphism in the metabolism of the anticonvulsant drug S-mephenytoin has been attributed to defective CYP2C19 alleles. This genetic polymorphism displays large interracial differences with the poor metabolizer (PM) phenotype representing 2-5% of Caucasian and 13-23% of Oriental populations. In the present study, we identified two new mutations in CYP2C19 in a single Swiss Caucasian...

Journal: :Pharmacogenetics and Genomics 2014
Taimour Y.Langaee, Hao-JieZhu, XinwenWang, NihalEl Rouby, John S.Markowitz, Joyce A.Goldstein, Julie A.Johnson,

Journal: :British Journal of Clinical Pharmacology 2010
Nuala A.Helsby, Wing-YeeLo, Ian J.Simpson, David M.Voss, Kaye E.Logan, MartinSearle, John B. W.Schollum, Janak R.De Zoysa,

Journal: :Pharmacogenetics and Genomics 2011
David A.Mrazek, Joanna M.Biernacka, Dennis J.O'Kane, John L.Black, Julie M.Cunningham, Maureen S.Drews, Karen A.Snyder, Susanna R.Stevens, Augustus JohnRush, Richard M.Weinshilboum,

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