نتایج جستجو برای: Epitope

تعداد نتایج: 19119  

Background: Hepatitis C virus (HCV) causes acute and chronic human hepatitis infections. Due to the high genetic diversity and high rates of mutations in the genetic material so far there is no approved vaccine against HCV. Materials and Methods: The aim of this study was to determination B and T cell conserved epitopes of E1 and E2 proteins from HCV and construction of a chimeric pepti...

Journal: :iranian journal of immunology 0
fatemeh hajighasemi department of immunology, school of public health, tehran university of medical sciences soheila gharagozlou department of immunology, school of public health, tehran university of medical sciences nasrin moheghi department of immunology, school of public health, tehran university of medical sciences roya ghods monoclonal antibody research center, avesina research center, tehran, iran jalal khoshnoodi department of immunology, school of public health, tehran university of medical sciences fazel shokri department of immunology, school of public health, tehran university of medical sciences

background: there are two subclasses of human iga (iga1 and iga2) that differ in antigenic properties and in chemical composition. the constant domains of α1 and α2 heavy chains have >95% sequence homology though major structural differences exist in the hinge region. quantitation of iga subclass levels depends on the availability of monoclonal antibodies (mabs) specific for conserved conformat...

Journal: :hepatitis monthly 0
leila pishraft sabet department of virology, school of public health, tehran university of medical sciences, tehran, ir iran; razi vaccine and serum research institute, karaj, ir iran tahereh taheri molecular immunology and vaccine research laboratory, pasteur institute of iran, tehran, ir iran arash memarnejadian hepatitis and hiv laboratory, pasteur institute of iran, tehran, ir iran talat mokhtari azad department of virology, school of public health, tehran university of medical sciences, tehran, ir iran fatemeh asgari department of virology, school of public health, tehran university of medical sciences, tehran, ir iran ramin rahimnia department of nano medicine, school of advanced technologies in medicine, tehran, ir iran

background hypervariability of hcv proteins is an important obstacle to design an efficient vaccine for hcv infection. multi-epitope vaccines containing conserved epitopes of the virus could be a promising approach for protection against hcv. objectives cellular and humoral immune responses against multi-epitope dna and peptide vaccines were evaluated in balb/c mice. materials and methods in th...

Journal: :iranian journal of applied animal science 2015
s. yousefi m. tahmoorespur m.h. sekhavati

brucellosis, produced by brucella species, is a disease that causes severe economic losses for livestock farms worldwide due to serious economic and medical consequences of this disease, many efforts have been made to prevent the infection through the use of recombinant vaccines based on brucella outer membrane protein (omp) antigens. in the present study, a wide range of on-line prediction sof...

Background and purpose: In 2019, the world has witnessed the emergence of a virus that caused acute respiratory distress syndrome in human with high mortality rates (approximately 3.7%). So far, no effective treatment has been proven against COVID-19. This study aimed at designing a multi-epitope vaccine combining several T-cell and B-cell epitopes of the SARS-CoV-2. Materials and methods: Bas...

زیبایی, سعید, حق‌پرست, ، علیرضا , دوستی, محمد , طهمورث‌پور, مجتبی , نصیری, ، محمدرضا ,

     Foot-and-mouth disease (FMD) is an extremely infectious and occasionally fatal viral disease with a rapid onset and a short course that affects cloven-hoofed animals and results in considerable financial losses. For this reason, availability of more reliable and efficient vaccines against Foot-and-mouth disease virus (FMDV) is felt as a necessity. The purpose of this study is to develop a ...

Bovine ephemeral fever is an acute and arthropod-borne viral disease of cattle and water buffalo which occurs seasonally in most of the world tropical and subtropical regions. The epizootic feature of the disease has been reported in Iran with serious economic consequences. The surface glycoprotein G of bovine ephemeral fever virus (BEFV) is composed of 4 antigenic sites (G1-G4) and plays the m...

Journal: :iranian journal of biotechnology 2008
malihe nazari jahantigh kamran ghaedi mohamad hossein nasr isfahani somayeh tanhaei farzaneh rabiee

epitope tagging is a method of expressing proteins whereby an epitope for a specific monoclonal antibody is fused to a target protein using recombinant dna techniques. the aim of this study was to sub-clone the peroxisomal protein (pep) cdna into a mammalian expression vector leading to the formation of a  chimeric pep-cdna containing the flag epitope. the flag-pep recombinant cdna was construc...

Farzaneh Rabiee Hossein Baharvand Kamran Ghaedi Khadijeh Karbalaei Malihe Nazari Jahantigh Maryam Ostad Sharif Marzieh Nematollahi Mehran Miroliaei Mohamad Hossein Nasr Isfahani Shahnaz Razavi Somayeh Tanhaei

Epitope tagging is a method of expressing proteins whereby an epitope for a specific monoclonal antibody is fused to a target protein using recombinant DNA techniques. The aim of this study was to sub-clone the peroxisomal protein (PEP) cDNA into a mammalian expression vector leading to the formation of a  chimeric PEP-cDNA containing the FLAG epitope. The FLAG-PEP recombinant cDNA was construc...

2003
Karin Fijnvandraat Wendy S. Bril Jan Voorberg

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