References 1. Inspections, compliance, enforcement, and criminal investigations: Novartis International AG 11/18/11 [warning letter]. Silver Spring (MD): Food and Drug Administration (US); 2011 Nov 18 [cited 2012 Sep 20]. Available from: www.fda.gov/ICECI/EnforcementActions/WarningLetters/ucm281843.htm 2. Lettre aux clients (15-16 février). Boucherville (QC): Sandoz Canada Inc.; 2012 Feb 15 [ci...

Flow cytometry (FCM) is a fluorescence-based single-cell experimental technology that is routinely applied in biomedical research for identifying cellular biomarkers of normal physiological responses and abnormal disease states. While many computational methods have been developed that focus on identifying cell populations in individual FCM samples, very few have addressed how the identified ce...

Evaluations of speech intelligibility based on a read passage are often used in the clinical situation to assess the impact of the disease and/or treatment on spoken communication. Although scale-based measures are often used in the clinical setting, these measures are susceptible to listener response bias. Automatic evaluation tools are being developed in response to some of the drawbacks of p...

europeans were the major actors of the world political scene in the 19th century. france sought to defeat its rivals in napaleanic era but the unification of other european powers lead to the defeat of france and the establishment of germany through the changes in the political map of europe. the german strategists, through entering international interactions challenged the other political play...

This study describes the management and products of the Gasconne cattle in two neighbouring countries (Spainand France), as a model study in trans-border breeds, analysing if they are significantly different depending on the place where they are located. Fifty-seven Gasconne breeders were interviewed (32 inSpainand 25 inFrance). The survey examined several aspects of the productive farming syst...

Background Even though there are many patient organizations across Europe, their role in impacting health policy decisions and reforms has not been well documented. In line with this, the present study endeavours to fill this gap in the international literature. To this end, it aims to validate further a previously developed instrument (the Health Democracy Index - HDI) measuring patient organi...

We report the discovery of the first trans-neptunian object, designated 2004 XR190, with a nearly-cirular orbit beyond the 2:1 mean-motion resonance. Fitting an orbit to 23 astrometric observations spread out over 12 months yields an orbit of a = 57.2 ± 0.4, e = 0.08 ± 0.04, and i = 46.6 •. All viable orbits have perihelia distances q > 49 AU. The very high orbital inclination of this extended ...