نتایج جستجو برای: NS3
تعداد نتایج: 2731 فیلتر نتایج به سال:
conclusions the pc-ns3 possesses the capacity to express ns3 in the mammalian cell line and demonstrated strong immunogenicity in a murine model. our primary results demonstrated that the immunogenic truncated region of ns3 could be used as a potential vaccine candidate against hepatitis c. results the pcdna3.1 plasmid harboring the coding sequence of ns3 (pc-ns3) was constructed and confirmed ...
بیماری اسهال ویروسی گاو (bvd)، یکی از بیماریهای مهم گاو است که با اسهال، سقط جنین، مردهزایی، بازگشت به فحلی و کاهش تولید شیر، خسارتهای اقتصادی هنگفتی را سبب میشود. این بیماری توسط ویروس اسهال ویروسی گاو (bvdv) از خانواده فلاویویریده و از جنس پستیویروس ایجاد میشود. برنامههای مراقبتی مناسب مانند جستجوی سرولوژیکی آنتیبادیهای تولید شده بر ضد ویروس bvd، اهمیت زیادی در پیشگیری و کنترل این ...
Introduction: Dendritic cells (DCs) have been recently employed as carriers for vaccines against several viral infections. The present study was designed to develop a prophylactic vaccine against hepatitis C virus (HCV) using DCs treated with Berberis vulgaris root extract (BRE), as a preclinical study. Methods: BRE was prepared and injected to female BALB/c mice for DCs expansion. The expanded...
Introduction: Hepatitis C virus (HCV) is one of the major medical problems. Human and chimpanzees are the only specific hosts which are naturally susceptible to HCV infection. Mice and other common laboratory animals are resistant to the virus, hence HCV prophylactic and therapeutic researches are very difficult and challenging. HCV non-structural protein 3 (NS3) is one of the most attractive t...
background hepatitis c virus (hcv) is able to down-regulate innate immune response. it is important to know the immune pathways that this virus interacts with. hcv non-structural protein 3 (ns3) plays an important role in this viral feature. hcv ns3 protein could affect the expression of antiviral protein such as viperin, and interleukin 28whichare important proteins in antiviral response. conc...
conclusions overall, results of present study were consistent with the data reported earlier base on 5’ ntr in iranian isolates and revealed genotype ir2 is major genotype in iranian hgv-positive patient. it means there are higher similarities between iranian and europe-usa in hgv ns3 gene. results nucleotide blast results emphasized that most similar sequences to ir ns3 sequences were those fr...
Background and Aims: Hepatitis C virus (HCV) infection is an important risk factor for the development of liver cancer. The HCV NS3 protein plays a key role in the virus life cycle and can affect normal cellular activities, such as cell proliferation, cell death, and cell signaling pathways. Moreover, it may influence malignancy development. Two cellular genes, heat shock protein 70 (HSP70) and...
هدف: تقریبا حدود 3 درصد از جمعیت جهان دارای عفونت هپاتیت c هستند و تخمین زده می شود که فقط یک نفر از پنج نفری که به تازگی عفونی شده اند یک پاسخ ایمنی کافی را برای پاکسازی عفونت داشته باشد. شکست پاسخ ایمنی میزبان حداقل بطور نسبی به علت توانایی ویروس در مخالفت با تولید و انتقال سیگنال از طریق اینترفرون های تیپ یک است. اغلب مطالعات نشان داده اند که ns3/4a پروتئاز ویروس هپاتیت c پاسخ اینترفرون را ح...
Hepatitis C virus (HCV) nonstructural protein 3 (NS3) possesses multiple enzyme activities. The N-terminal one-third of NS3 primarily functions as a serine protease, while the remaining two-thirds of NS3 serve as a helicase and nucleoside triphosphatase. Whether the multiple enzyme activities of NS3 are functionally interdependent and/or modulated by other viral NS proteins remains unclear. We ...
The N-terminal 198 residues of NS3 (NS3-N) of Hepatitis C virus (HCV) subtype 1b obtained from 29 patients, as well as full-length NS3 (NS3-Full), were analysed for their subcellular localization, interaction with the tumour suppressor p53 and serine protease activity in the presence and absence of the viral cofactor NS4A. Based on the subcellular-localization patterns in the absence of NS4A, N...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید