background: besides acute lethal cyanide poisoning, its chronic intoxication may also produce some pathologic effects on different tissues that precedes alterations in biochemical parameters. the present study was aimed to evaluate the effects of sublethal cyanide exposure on some tissue enzyme activities in liver and kidney of rats. methods: twelve male rats were divided into two groups as fol...

conclusions it seems that testosterone in low dose, i.e. physiologic dose, protects kidneys against cp-induced nephrotoxicity; however, special care is needed in cp therapy of patients with high levels of ts. results cp increased the serum levels of blood urea nitrogen (bun), creatinine (cr), and malondialdehyde (smda) as well as kidney weight (kw), bodyweight (bw) loss, and kidney tissue damag...

background: diazinon is a widely used organophosphate insecticide which is applied against plant pests. this compound has various side effects because it acts as an acetyl cholinesterase enzyme inhibitor. objective: the aim of present study was to investigate the effects of diazinon on pituitary–gonad axis and ovarian histological changes in rats. materials and methods: in total 50 female wista...

background: studies have shown that physalis alkekengi reduces implantation and induces antifertility in rat. in iranian traditional medicine it is believed that this plant has abortifacient and antifertility activities. objective: the goal of this study was to evaluate the effect of physalis alkekengi ripe fruit hydroalcoholic extract (pfe) on uterine contractility and its possible mechanism(s...

objective(s) in this study, effects of chronic administration of oral natural honey against ischemia/reperfusion (i/r)-  induced cardiac arrhythmias were investigated in isolated rat heart. materials and methods male wistar rats were divided into four groups (n= 10-14 rats in each group) and fed with natural honey (1%, 2% and 4% dissolved in the drinking water) for 45 days except for the contro...

background: danae racemosa is a strong antioxidant and antioxidants have significant effects on spermatogenesis, sperm biology and oxidative stress, and changes in antioxidant capacity are considered to be involved in the pathogenesis of chronic diabetes mellitus. objective: because stz causes testicular dysfunction and degeneration under situations of experimentally induced diabetes in animal ...

amiodarone is used in treatment of cardiac arrhythmias. therapeutic use of amiodarone is limited by its side effects, including pulmonary toxicity. human placenta extract (hpe) contains a variety of bio-active substances. thus, the present study aimed to quantitatively evaluate the protective effects of hpe on the structural lung changes induced by amiodarone using stereological methods. spragu...

acute  pancreatitis (ap) is a common clinical  disease  caused mainly by gallstone impacting  the distal common bile-pancreatic duct and alcohol abuse, but other potential causes as  endoscopic  retrograde cholangiopancreatography  (ercp),  intra duct papillary mucinous tumor and hypercalcemia are claimed .  the incidence of ap has been increasing in recent years . accordingly, ap is a multifac...

the specificity of gentamicin for vitamin e deficiency-associated oxidative stresses in the renal proximal convoluted tubules is apparently related to its ability to increasingly facilitate generation of radical species in mitochondria. to determine the ways in which vitamin e manage the currently processes, we conducted a prospective study aimed to investigate the tubular preserving effect of ...