نتایج جستجو برای: a1 receptor

تعداد نتایج: 609643  

Journal: :basic and clinical neuroscience 0
mohmmad zamani m. katebi mehdi mehdizadeh laya kafami fatemeh malek mansooreh soleimani

introduction: stroke is one of the most important reasons of death. hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. the ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. the a1 adenosine receptoras an endogenous l...

Hossein Hosseinzadeh, Jamal Shamsara, Mahmoud R. Jafari,

Background: In this study, the effects of three structural analogues of adenosine upon proliferation of human tumor cells were investigated. Previous research showed a cytotoxic effect of adenosine via A3 receptor and A1 receptor and sometimes this effect was receptor independent. The researches showed a differential cytotoxic effect of adenosine and its A3 agonists on cancerous cells, while ot...

Journal: :iranian biomedical journal 0
حسین حسین زاده hossein hosseinzadeh محمود آر جعفری mahmoud r. jafari جمال شمس آرا jamal shamsara

background: in this study, the effects of three structural analogues of adenosine upon proliferation of human tumor cells were investigated. previous research showed a cytotoxic effect of adenosine via a3 receptor and a1 receptor and sometimes this effect was receptor independent. the researches showed a differential cytotoxic effect of adenosine and its a3 agonists on cancerous cells, while ot...

Journal: :research in pharmaceutical sciences 0
mehdi nikbakht dastjerdi mohammad zamani rarani ali valiani mohsen mahmoudieh

adenosine receptor family especially a1 type is expressed in breast cancer cells in which p53 and caspase genes are wild-type. the aim of this study was to investigate the correlation between a1 receptor and either cell apoptosis or proliferation and also to recognize the relationship between this receptor and p53 and the expression of caspases 3, 8 and 9 in mcf-7 cell line. mcf-7 cells were tr...

Fatemeh Malek, Laya Kafami, M. Katebi, Mansooreh Soleimani, Mehdi Mehdizadeh, Mohmmad Zamani,

Introduction: Stroke is one of the most important reasons of death. Hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. The ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. The A1 adenosine receptoras an endogenous l...

Journal: :cell journal 0

introduction: the role of adenosine a1 receptors of the amygdala on entorhinal cortex kindled seizures was investigated. material and methods: animals were kindled by daily electrical stimutation of entorhinal cortex. in the full kindled animals, n6-cyclohexyladenosine (cha 10, 50, 100, 500óm), an adenosine a1 receptor agonist and 8-cyclopentyl- 1, 3, dimethylxanthine (cpt, 10, 20 óm), an adeno...

Journal: :journal of paramedical sciences 0
seyed mohammad mahdavi department of biology, science and research branch, islamic azad university, tehran, iran. mostafa rezaei-tavirani proteomics research center ,shahid beheshti university of medical sciences, tehran, iran. abdolrahim nikzamir faculty of medicine, shahid beheshti university of medical sciences, tehran, iran. abdolreza ardeshirylajimi department of stem cell biology, stem cell technology research center, tehran, iran.

due to the increasing presence of electromagnetic radiation in advanced societies, investigation of the effects of this radiation on humans has attracted the interest of many researchers. the non- ionizing radiation can induce numerous effects through biomolecules in the tissue and cells. in the current study, effects of 12 hz electromagnetic waves investigated on neuronal hormone levels in rat...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011

J Mirnajafizadeh M Zeraati S Namvar Y Fathollahi

In this study the role of adenosine A1 receptors of the CA1 region of hippocampus on piriform cortex–kindled seizures was investigated in rats. Obtained results showed that in kindled animals, bilateral microinjection of N6–cyclohexyladenosine (CHA), an adenosine A1 receptor agonist, at doses of 10 and 100 mM into the hippocampal CA1 region decreased the afterdischarge duration (ADD), stage 5 s...

Background and Objectives: Few studies have examined so far the effect of adenosine receptors’ injection and its downstream pathway on the liver’s fat metabolism. The aim of this study was to investigate the type of aerobic exercise and adenosine on the expression of sterol regulatory binding protein 1c SREBP-1c and the adenosine receptor A1 in the liver in the rats fed with high-fat foods. Mat...

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