objective(s):therapies with high levels of oxygen are commonly used in the management of critical care. however, prolonged exposure to hyperoxia can cause acute lung injury. although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (hali).   materials a...

increased arginase activity in the airways decreases l-arginine and causes deficiency of bronchodilating and anti-inflammatory nitric oxide (no) in asthma. as, it is suggested that l-arginine may have therapeutic potential in asthma treatment, we aimed to investigate the effects of inhaled l-arginine on oxygen saturation (sao₂) and airway histology in a murine model of acute asthma. twenty eigh...

cyclizine (1-benzhydryl-4-methyl-piperazine, cas 82-92-8, cyc, i), a piperazine derivative, belongs to h1 antihistamine group of drugs that shows such pharmacological properties as anti-inflammatory, anti-allergic and anti-platelet effects, similar to other h1-receptor antagonists. in this study, two new tolyl and cumene derivatives of i (1-ethyl-4-[(p-isopropylphenyl) (p-tolyl) methyl]-piperaz...

the effects of hydroalcoholic extract (he) of curculigo orchioides gaertn. rhizome (hypoxidaceae) and its alkaloidal and non-alkaloidal fractions (af) and (naf) were evaluated in carrageenan-induced paw edema experimental models of inflammation. the oral administration of he, their af and naf fractions were used at doses of 100, 300 and 500 mg/kg. the effect produced by the he, af and naf fract...

Beta-2 adrenoceptors in blood vessels are one of the active factors that play a role in regulation of tissue blood flow. in diabetic angiopathy, responsiveness of these receptors is decreased, while that is increased in inflammation. According to these opposite effects, the aim of this study was to investigate the vasodilatory response of knee joint blood vessels to salbutamol (Beta-2 adreno...

beta-2 adrenoceptors in blood vessels are one of the active factors that play a role in regulation of tissue blood flow. in diabetic angiopathy, responsiveness of these receptors is decreased, while that is increased in inflammation. according to these opposite effects, the aim of this study was to investigate the vasodilatory response of knee joint blood vessels to salbutamol (beta-2 adrenocep...

Ischemic stroke has been classified as a merely thrombotic disease, so the main goal of its treatment is the recanalization of the occluded vasculature. However, despite fast restoration of blood circulation, progressive stroke still develops in many patients, which has led to the concept of reperfusion injury.  The underlying mechanism is only partly known. Though, it is accepted now, tha...

inflammatory  disease such as rheumatiod artheritis increase blood flow to joints.kaolin is one of substances injected into the joints in order to induce experimental acute joint inflammation the aim of this study was to determine the role played by nervous system in this model of acute in flammation.in the rabbit.evans blue technique was used to assess articular inflammation.the results indica...

Canarium L. is used in folk medicine as anti-inflammatory, antibacterial, antifungal, antitumor, heptoprotective, antioxidant, and anti diabetic properties. The present study investigeated the invivo anti-inflammatory activity of  essential oil obtained by hydrodistillation of resin of Canarium strictum Roxb. In the current study, anti-inflammatory activity of essential oil of...

Apple Cider Vinegar (ACV) is a natural compound that is used mainly in numerous food preparations. During the last few decades, ACV has been used for various therapeutic purposes in different countries. One of its main applications by people in Iran and other countries has been as an oral traditional remedy to control chronic pain in arthritis. In this study, ACV’s effects on acute and chronic ...