In this paper we describe an initial reproducibility study of 12 proprietary compounds followed by the assessment of 51 marketed pharmaceuticals and, lastly, a summary of the data so far from 2698 proprietary compounds from the Johnson & Johnson (J&J) compound library, in the yeast GreenScreen assay (GSA). In this assay, a reporter system in the yeast cells employs the DNA damage inducible prom...

BACKGROUND Different parts of Podocarpus henkelii have been used in many cultures around the world to treat ailments such as cholera, stomach diseases, rheumatism, cancer, canine distemper in dogs and gall sickness in cattle. The aim of this study was to evaluate the biological activity and toxicity of isolated compounds from Podocarpus henkelii after an earlier study indicated a promising acti...

The early and accurate diagnosis of the mucopolysaccharidoses remains a problem for the clinical laboratory. Reported here is the systematic compari­ son of the ability of three common glycosaminoglycanuria screening proce­ dure (the Berry spot test, the AMES MPS® spot test, and the gross acid albumin turbidity test) to detect the mucopolysaccharidoses. These tests were run on random urine samp...

Additively manufactured (AM) supercapacitor platforms are fabricated from bespoke filaments, which comprised of electro-conductive graphene (20 wt%) incorporated polylactic acid (80 wt%), via fused deposition modeling and denoted as G/AMEs. The G/AMEs shown to be capable acting a template for the electrodeposition metals/metal oxides, in particular MoO2 nanowires (MoO2-G/AMEs), subsequently exp...

Waterpipe smoking has become a global youth trend especially in the Middle East countries and Iran . The aim of this study was to determine the mutagenic effects of three most popular flavored tobaccos by four different salmonella typhimurium strains and compare the possible mutagenic effects of the test samples. Ames mutagenicity assessment was conducted according to the OECD guideline using T...

A statistical characterization of negative control data in the Ames Salmonella/microsome reverse mutation test was performed using data obtained at Takeda Analytical Research Laboratories during January 1989 to April 1990. The lot-to-lot variability of bacterial stock cultures and day-to-day variability of experiments were small for Salmonella typhimurium strains TA1535 and TA1537 and Escherich...