Purpose: To measure CXCL10 as angiostatic, and CXCL1, CXCL12 as angiogenic chemokines in the tissues of wounds of diabetics following treatment with insulin, angipars (a herbal Iranian drug) and a combination of angipars and insulin. Methods: Forty eight male Wistar rats weighing 200 250 g were used. The induction of diabetes was carried out with 50 mg/kg of STZ (streptozotocin). Approximately,...

BACKGROUND AND THE PURPOSE OF THE STUDY There are strong evidences linking overproduction of reactive oxygen species and periodontal diseases. The aim of this study was to evaluate efficacy of Angipars a natural potent anti oxidative agent on markers of the oxidative damages and periodontal inflammation in the rat. METHODS Periodontitis was induced by single injection of lipopolysaccharide (L...

BACKGROUND AND THE PURPOSE OF THE STUDY Diabetic neuropathy is the most common diabetic complication that often is accompanied by significant morbidity, mortality and economic burden. The purpose of this study was evaluation of effect of Semelil (ANGIPARS™), a new herbal drug for treatment of diabetic foot ulcers or diabetic peripheral neuropathy. METHODS In this double blind clinical trial, ...

Diabetes mellitus is the most common metabolic disease with a high prevalence rate in human society that eventually leads to the peripheral nervous system complications in a great number of patients. In the present study, the effects of Angipars on nerve conduction velocity, histological alterations, and behavioral indices were investigated. Diabetes was induced in male rats by intraperitoneal ...

OBJECTIVES Chlorpyrifos (CP) is a broad-spectrum organophosphorus pesticide used extensively in agricultural and domestic pest control, accounting for 50% of the global insecticidal use. In the present study, protective effects of two selenium-enriched strong antioxidative medicines IMOD and Angipars were examined in human lymphocytes treated with CP in vitro. MATERIALS AND METHODS Isolated l...

abstractintroduction: diabetes mellitus is the most common human metabolic disease and chronic non healing diabetic foot ulcers are a critical complication for these patients. angipars is a new herbal extract which has been introduced to accelerate healing of these ulcers. the purpose of this study was to investigate the efficacy and safety of oral angipars in patients with chronic diabetic foo...

in the present study, free-radical-scavenging and antioxidant activities of angipars™, an herbal extract which has been registered as a therapeutic drug for diabetic foot ulcer, were examined. we investigated the protective effect of angipars™ on cytotoxicity produced by exposure to h2o2 (300 µm) in hepg2 and a549 cell lines, using mtt assay, glutathione (gsh) content analysis, and lipid peroxi...

Introduction: Diabetes is the most common cause of peripheral nerve involvement. Evaluating the effect of antioxidants on diabetic neuropathic pain is important. This study aimed at evaluating the effects of Angipars medicine in the treatment of neuropathic hyperalgesia in single dose streptozotocin-induced diabetic rats. Correspo...

objective(s):  chlorpyrifos (cp) is a broad-spectrum organophosphorus pesticide used extensively in agricultural and domestic pest control, accounting for 50% of the global insecticidal use. in the present study, protective effects of two selenium-enriched strong antioxidative medicines imod and angipars were examined in human lymphocytes treated with cp in vitro. materials and methods: isolate...

Objective(s):  Chlorpyrifos (CP) is a broad-spectrum organophosphorus pesticide used extensively in agricultural and domestic pest control, accounting for 50% of the global insecticidal use. In the present study, protective effects of two selenium-enriched strong antioxidative medicines IMOD and Angipars were examined in human lymphocytes treated with CP in vitro. Materials and Methods: Isolate...