OBJECTIVE Rheum turkestanicum (R. turkestanicum) rhizomes have been used in Iranain traditional medicine as an anti-diabetic agent. The purpose of the present investigation was to evaluate the anti-diabetic and antioxidant activities of R. turkestanicum rhizome extract in streptozotocin-induced diabetic rats. MATERIALS AND METHODS Diabetes was induced by a single intraperitoneal injection of ...

AIMS Oxidative stress and apoptosis are among the earliest lesions of diabetic retinopathy. This study sought to examine the anti-oxidative and anti-apoptotic effects of α-melanocyte-stimulating hormone (α-MSH) in early diabetic retinas and to explore the underlying mechanisms in retinal vascular endothelial cells. METHODS Sprague-Dawley rats were injected intravenously with streptozocin to i...

Objective: Tamarindus indica Linn.(T.indica) is a well-known plant used in traditional medicine. The plant is popular for its antidiabetic activity. However, effect so f its aqueous fruit pulp extract on carbohydrate hydrolyzing enzymes and its glucose uptake potential were not explored. Materials and Methods: The antidiabetic activity w...

Helicanthes elasticus (Desr.) Danser is a member of family Loranthaceae which found widely growing on mango trees in southern India. Alkaloids, carbohydrate, steroids, tannins, saponins, phenols, flavonoids and triterpenoids are mainly believed to be responsible for its wide therapeutic actions. It known possess medicinal activities such as antimicrobial activity, immunomodulatory hepatoprotect...

Objective(s): The present study sought to evaluate the beneficial effects of histidine (His) on oxidative stress, tumor necrosis factor alpha (TNF-α), renal histological alterations and anti-oxidant enzymes gene expressions in type 2 diabetic rats.Materials and Methods: Streptozotocin/nicotinamide (STZ/NA) induced diabetic rats were used...

Introduction: Salvia hispanica L. is an annual herbaceous plant commonly known as "Chia", native of southern Mexico and northern Guatemala. The aim this study isolation, identification secondary metabolites evaluation biological activities ethyl acetate fraction aerial parts. Methods: Air dried powdered parts was extracted by maceration fractionated using light petroleum, dichloromethane solven...

Ocular anti-vascular endothelial growth factor (VEGF) therapy represents one of the most significant advances in modern medicine. The introduction and widespread use of ocular anti-VEGF therapy for age-related macular degeneration heralded a new era in the treatment of vascular and exudative diseases of the retina. Its expanding indications now include diabetic macular edema and proliferative d...