نتایج جستجو برای: atl granzyme htlv

تعداد نتایج: 10406  

2012
Hiroo Hoshino

Human T cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T cell leukemia (ATL) and HTLV-1 - associated myelopathy and tropical spastic paraparesis (HAM/TSP). HTLV-1 has a preferential tropism for CD4 T cells in healthy carriers and ATL patients, while both CD4 and CD8 T cells serve as viral reservoirs in HAM/TSP patients. HTLV-1 has also been detected other cell types, includ...

Journal: :Blood 1997
A Imura T Hori K Imada S Kawamata Y Tanaka S Imamura T Uchiyama

We demonstrated previously that OX40 and its ligand, gp34, directly mediate adhesion of activated normal CD4+ T cells, as well as human T-cell leukemia virus type I (HTLV-I)-transformed T cells to vascular endothelial cells. In the present study, we examined expression of OX40 on fresh leukemic cells from patients with adult T-cell leukemia (ATL) and its possible involvement in cell adhesion. F...

Journal: :Journal of reproductive immunology 2000
T Fujino Y Nagata

Human T-lymphotropic virus type I (HTLV-I), a causative agent of adult T-cell leukemia, (ATL) is transmitted from mother to child. ATL cells originate from the CD4 subset of peripheral T cells. The main route of mother-to-child transmission is postnatal breast-feeding. Refraining from breast-feeding or limiting the duration of breast-feeding can reduce the risk of mother-to-child transmission. ...

2014
Takashi Ohashi Takafumi Nakamura Minoru Kidokoro Xianfeng Zhang Hisatoshi Shida

Adult T cell leukemia (ATL) is a malignant lymphoproliferative disease caused by human T cell leukemia virus type I (HTLV-I). To develop an effective therapy against the disease, we have examined the oncolytic ability of an attenuated vaccinia virus (VV), LC16m8Δ (m8Δ), and an HTLV-I Tax-specific cytotoxic T lymphocyte (CTL) line, 4O1/C8, against an HTLV-I-infected rat T cell line, FPM1. Our re...

Background and Aims: Human T-lymphotropic virus type 1 (HTLV-1) is a member of retroviridae family that causes ATL and HAM/TSP. Many inflammatory diseases are associated with this virus, such as Sjögren's syndrome, Hashimoto's thyroiditis, Uveitis and also Atherosclerosis. HTLV-1 performs in long latency period and can activate the immune responses in coronary vessels. Activated immune sys...

2016
Yumiko Kasugai Noriaki Yoshida Koichi Ohshima Keitaro Matsuo Masao Seto Shinobu Tsuzuki

Adult T-cell leukemia/lymphoma (ATL) develops in human T-cell leukemia virus type 1 (HTLV-1) carriers. Although the HTLV-1-encoded HBZ gene is critically involved, HBZ alone is insufficient and additional, cooperative "hits" are required for the development of ATL. Candidate cooperative hits are being defined, but methods to rapidly explore their roles in ATL development in collaboration with H...

Journal: :Blood 2002
Marwan E El-Sabban Raghida Abou Merhi Hounaida Abi Haidar Bertrand Arnulf Hilda Khoury Jihane Basbous Julie Nijmeh Hugues de Thé Olivier Hermine Ali Bazarbachi

The role of angiogenesis in the growth and metastasis of solid tumors is well established. However, the role of angiogenesis in hematologic malignancies was only recently appreciated. We show that HTLV-I-transformed T cells, but not HTLV-I-negative CD4(+) T cells, secrete biologically active forms of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and, accord...

Journal: :iranian journal of basic medical sciences 0
sanaz ahmadi ghezeldasht research centre for hiv/aids, htlv and viral hepatitis, iranian academic centre for education, culture & research (acecr), mashhad branch, mashhad, iran abbas shirdel inflammation and inflammatory diseases research centre, medical school, mashhad university of medical science, mashhad, iran. mohammad ali assarehzadegan department of immunology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran tahereh hassannia internal medicine dept, medical school, arak university of medical sciences, arak- iran hosian rahimi inflammation and inflammatory diseases research centre, medical school, mashhad university of medical science, mashhad, iran. rahele miri research centre for hiv/aids, htlv and viral hepatitis, iranian academic centre for education, culture & research (acecr), mashhad branch, mashhad, iran

the study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. the processes ranging from viral infection to progressing malignancy are slow and usually insufficient for establishment of transformed cells that develop cancer in only a mi...

1997
Paul D Drew Ameer M Gado Rachel D Canning James W Nagle Anindya M Dehejia Mihael H Polymeropoulos William E Biddison Steven Jacobson Kevin G Becker

We report the cloning and characterization of a novel cDNA termed C2H2-546 which encodes a C2H2-type zinc ®nger protein. C2H2-546 RNA is expressed in the HTLV-1 infected T cells examined which were derived from HAM-TSP patients, but not in T cells derived from ATL patients. The C2H2-546 gene is conserved in humans and primates and maps to chromosome 10q11.2, a site associated with a variety of ...

Journal: :Blood 2003
Rihab Nasr Andreas Rosenwald Marwan E El-Sabban Bertrand Arnulf Pierre Zalloua Yves Lepelletier Françoise Bex Olivier Hermine Louis Staudt Hugues de Thé Ali Bazarbachi

Adult T-cell leukemia (ATL) is a severe chemotherapy-resistant malignancy associated with prolonged infection by the human T cell-lymphotropic virus 1 (HTLV-1) retrovirus. Although the Tax viral transactivator is clearly an oncogene, the role of its continuous expression in the maintenance of the transformed phenotype is controversial. Because arsenic trioxide (As) and interferon alpha (IFN) sy...

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