Spontaneous mutations were accumulated in 100 replicate lines of Caenorhabditis elegans over a period of approximately 50 generations. Periodic assays of these lines and comparison to a frozen control suggest that the deleterious mutation rate for typical life-history characters in this species is at least 0.05 per diploid genome per generation, with the average mutational effect on the order o...

this paper presents a simplifiedlagrangian multiplier based algorithm to solve the fixed head hydrothermalscheduling problem. in fixed head hydrothermal scheduling problem, waterdischarge rate is modeled as quadratic function of hydropower generation andfuel cost is modeled as quadratic function of thermal power generation. thepower output of each hydro unit varies with the rate of water discha...

Laser pulse heating of solid surface and entropy generation during the heating process are considered. Time exponentially decaying pulse is accommodated in the analysis and the laser pulse parameter (b1/b2) resulting in minimum entropy generation rate is computed. Analytical solutions for temperature rise are presented and volumetric entropy generation rate is formulated. Two laser pulses resul...

Heart rate variability (HRV) is a recognized risk factor in many disease states (Bravi et al., 2011; Sacha et al., 2013a). However, HRV is significantly correlated with an average heart rate (HR), and this association is both physiologically and mathematically determined. The physiological determination comes from the autonomic nervous system activity (Task Force of the European Society of Card...

In vivo plasminogen responses to various stimuli were studied. Plasminogen-(125)I was prepared and used first for metabolic studies of plasminogen in control dogs. The average results were: the plasma plasminogen, 29.3+/-4.1 (SD) mg/kg; the interstitial plasminogen, 8.79+/-4.47 (SD) mg/kg; the half-life of plasma plasminogen-(125)I, 2.81+/-0.24 (SD) days; the fractional direct catabolic rate of...

In this talk, we propose the average renewal cycle (ARC) model to estimate packet loss probability for on-oo traac sources in a statistically mul-tiplexed rst-in-rst-out (SMF) switch. SMF is a widely adopted architecture for switches, routers, and many other types of communications devices. In ARC, a worst case scenario on the cell loss process is derived for aggregated traac states, so that we...

Based on the idea that selective neutrality is the limit when the selective disadvantage becomes indefinitely small, a model of neutral (and nearly neutral) mutations is proposed that assumes that the selection coefficient (s') against the mutant at various sites within a cistron (gene) follows a Gamma distribution; f(s') = alpha(beta)e(-alphas')s'(beta-1)/Gamma(beta), in which alpha = beta/ s'...